Methocarbamol

Skeletal Muscle Relaxant Combinations Carisoprodol Compound—carisoprodol, aspirin Mexaphen—chlorzoxazone, acetaminophen Lobac—salicylamide, phenyltoloxamine, acetaminophen Norgesic Fbrte—orphenadrine citrate, aspirin, caffeine Norgesic—orphenadrine citrate, aspirin, caffeine Robaxisal—methocarbamol, aspirin Sodol Compound—carisoprodol, aspirin Soma Compound—carisoprodol, aspirin... 

Colorimetric procedures used In steroid assays are often subject to drug Interference. In the determination of 17-Ketosterolds by the Zimmerman reaction, drugs with the 17-Keto basic structure such as ascorbic acid, morphine and reserplne will cause Increased values. In the determination of 17,21 -dlhydroxysterolds by the Porter-Sllber reaction the dlhydroxy-acetone chain Is the reactive unit. Drugs like meprobamate, chloral hydrate, chloropromazlne and potassium Iodide will Interfere with this reaction and cause elevated values. In the colorimetric determination of vanlllylmandellc acid (VMA) by a dlazo reaction, drugs like methocarbamol and methyl dopa cause... 

Where pain is worsened by muscle spasm, oral muscle relaxants may serve as a useful adjunct to therapy.25 These agents include baclofen, metaxalone, methocarbamol, carisoprodol, and cyclobenzaprine. Muscle relaxants may decrease spasm and stiffness associated with either acute or chronic musculoskeletal disorders. These agents should be used with caution because they all may cause sedation, especially in combination with alcohol or narcotic analgesics. 

Fenvalerate toxicity is antagonized by atropine sulfate or methocarbamol, which may be effective in treating severe cases of poisoning (Hiromori et al. 1986). Conversely, some compounds exacerbate the toxicity of fenvalerate and interfere with a desired use. Domestic cats (Felis domes-ticus) treated with Fendeet (an aerosol mixture of fenvalerate and A-A-diethyl-m-toluamide) to control fleas and ticks sometimes show signs of toxicosis, such as tremors, hypersalivation, ataxia, vomiting, depression, and seizures. Signs usually appeared within hours of topical application, and females and juveniles seem to be the most sensitive groups. The demonstrated ability of N-N-diethyl-m-toluamide to enhance the dermal absorption of fenvalerate is the probable cause of toxicosis (Dorman et al. 1990). 

Hiromori, T., T. Nakanishi, S. Kawaguchi, H. Sako, T. Suzuki, and J. Miyamoto. 1986. Therapeutic effects of methocarbamol on acute intoxication by pyrethroids in rats. Jour. Pestic. Sci. 11 9-14. 

Centrally acting muscle relaxants are also widely used (baclofen, cyclobenzaprin, carisoprodol, methocarbamol, chlorphenesin, chlorzoxazone, orphenadrine, and... 

Methocarbamol Methocarbamol, 3-(2-methoxyphenoxy)-l,2-propanediol-l carbamate (15.3.13), is synthesized by successive reaction with phosgene and then ammonia into 3-(2-methoxyphenoxy)propanediol-1,2 [34,35]. 

Methocarbamol suppresses multisynaptic pathways in the spinal cord. It is used for relieving spasms and skeletal muscle pain as well as for treating tetanus. Synonyms of this drug are delaxin, forbaxin, robamol, robaxin, and tresortil. 

Chlorphenesin Chlorphenesin, 3-(4-chlorophenoxy)-l,2-propanediol (15.3.14), is synthesized in the same manner as methocarbamol from 3-(4-chlorophenoxy)-1,2-propanediol [36-38]. 

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