Relax - Methocarbamol

Relact - Nitrazepam Relaksin - Meprobamate Reiasom -Carisoprodol Relax - Methocarbamol Relaxan - Gallamine trlethiodide Relaxar - Mephenesin Relaxo-Powel - Carisoprodo)... 

The client is admitted with severe low back pain and prescribed the muscle relaxant methocarbamol (Robaxin), FVPB every 8 hours. WTiich nursing intervention has priority when administering this medication ... 

In a single healthy volunteer, the chiral skeletal muscle relaxant methocarbamol was found to possess stereoselectivity in plasma concentrations after intravenous administration. Based on the plasma concentration vs. time curve, the S enantiomer appeared to be cleared more rapidly than antipode, although pharmacokinetic data were not reported [215]. 

Epoxide rings can be cleaved by phenoxides. Propose a synthesis of the muscle relaxant methocarbamol using this fact. 

Skeletal Muscle Relaxant Combinations Carisoprodol Compound—carisoprodol, aspirin Mexaphen—chlorzoxazone, acetaminophen Lobac—salicylamide, phenyltoloxamine, acetaminophen Norgesic Fbrte—orphenadrine citrate, aspirin, caffeine Norgesic—orphenadrine citrate, aspirin, caffeine Robaxisal—methocarbamol, aspirin Sodol Compound—carisoprodol, aspirin Soma Compound—carisoprodol, aspirin... 

Where pain is worsened by muscle spasm, oral muscle relaxants may serve as a useful adjunct to therapy.25 These agents include baclofen, metaxalone, methocarbamol, carisoprodol, and cyclobenzaprine. Muscle relaxants may decrease spasm and stiffness associated with either acute or chronic musculoskeletal disorders. These agents should be used with caution because they all may cause sedation, especially in combination with alcohol or narcotic analgesics. 

Centrally acting muscle relaxants are also widely used (baclofen, cyclobenzaprin, carisoprodol, methocarbamol, chlorphenesin, chlorzoxazone, orphenadrine, and... 

Methocarbamol (Robaxin) [Skeletal Muscle Relaxant/ Centrally Acting] Uses Relief of discomfort associated w/ painful musculoskeletal conditions Action Centrally acting skeletal muscle relaxant Dose Adults. 1.5 g PO qid for 2-3 d, then 1-g PO qid maint therapy IV form rarely indicated Peds. 15 mg/kg/dose IV, may repeat PRN (OK for tetanus only), max 1.8 g/mVd for 3 d Caution Sz disorders [C, +] Contra MyG, renal impair Disp Tabs, inj SE Can discolor urine drowsiness, GI upset Interactions T Effects Wf CNS depressant, EtOH EMS May cause blurred vision and orthostatic hypotension use caution w/ CNS depressants concurrent EtOH use can T CNS depression OD May cause drowsiness, light-headedness, syncope, and slow shallow breathing symptomatic and supportive... 

Geriatric Considerations - Summary Methocarbamol is a skeletal muscle relaxant that at higher doses can cause CNS depression. It appears to have modest clinical benefits and is most often used for acute muscle discomfort as compared to chronic musclepain. Transient CNS depressant effects place the older adult at riskforfallsand related accidents when taking this drug. 

Muscle relaxants and antispasmodics methocarbamol (Robaxin), carisoprodol (Soma), chlorzoxazone (Paraflex), metaxalone (Skelaxin), cyclobenzaprine (Flexeril), and oxybutynin (Ditropan) Do not consider the extended-release Ditropan XL Most muscle relaxants and antispasmodic drugs are poorly tolerated by elderly patients, because these cause anticholinergic adverse effects, sedation, and weakness. Additionally, their effectiveness at doses tolerated by elderly patients is questionable. High... 

Most muscle relaxants are absorbed fairly easily from the gastrointestinal tract, and the oral route is the most frequent method of drug administration. In cases of severe spasms, certain drugs such as methocarbamol and orphenadrine can be injected intramuscularly or intravenously to permit a more rapid effect. Likewise, diazepam and dantrolene can be injected to treat spasticity if the situation warrants a faster onset. As discussed earlier, continuous intrathecal baclofen administration may be used in certain patients with severe spasticity, and local injection of botulinum toxin is a possible strategy for treating focal dystonias and spasticity. Metabolism of muscle relaxants is usually accomplished by hepatic microsomal enzymes and the metabolite or intact drug is excreted through the kidneys. 

BACLOFEN, METHOCARBAMOL, TIZANIDINE ALCOHOL t sedation Additive effect Warn patients advise them to drink alcohol only in moderation and not to drive if they have drunk any alcohol and are taking these muscle relaxants... 

Methocarbamol was developed in 1956 in the laboratories of A.H. Robins. Studies were directed towards the development of propanediol derivatives which possessed muscle relaxant properties superior to those of mephenesin, which had low potency and a short duration of action1 >2,3. 

Acsal.Par,Ph.mepro- Separation muscle-relaxant-bamate,methocarbamol,-analgesic mixtures carisoprodol. chlorzoxazone... 

Methocarbamol is a centrally acting skeletal muscle relaxant. A carbamate derivative of guaifenesin (1.5 g p.o. q.i.d.), methocarbamol is used as an adjunct in acute, painful musculoskeletal conditions and in supportive therapy in tetanus management. 

Souri E, Sharifzadeh M, Farsam H, et al. Muscle relaxant activity of methocarbamol... 

Methocarbamol (Robaxin), a muscle relaxant, to a client with chronic back pain. 

I. Pharmacology. Methocarbamol is a centrally acting muscle relaxant. It does not directly relax skeletal muscle, and it does not depress neuromuscular transmission or muscle excitability muscle relaxation is probably related to its sedative effects. After intravenous administration, the onset of action is nearly immediate. Elimination occurs by hepatic metabolism, with a serum half-life of 0.9-2.2 hours. 

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