Centrally acting muscle relaxants

J -methylpyrrolidone by conversion to the imine ( 7) by sequential reaction with triethyloxonium tetraf1uoroborate and then anhydrous ammonia. When this is reacted with 2,6-dimethyl-phenyl i socyanate, the centrally acting muscle relaxant xilobam (8) is formed. ... [Pg.56]

Therapeutic Function Centrally acting muscle relaxant... [Pg.29]

CENTRALLY ACTING MUSCLE RELAXANTS AND ANTIPARKINSONISM AGENTS 15... [Pg.1]

Since 1958, chlormezanone was marketed by Sanofi-Winthrop, under the brand name Trancopal, as a centrally acting muscle relaxant in lower back pain [22,23]. Evidence of the efficacy of chlormezanone was, however, limited and of poor quality. In comparison to other centrally acting muscle relaxants in lower back pain, there... [Pg.6]

Centrally acting muscle relaxants (A) lower muscle tone by augmenting the activity of intraspinal inhibitory interneurons. They are used in the treatment of painful muscle spasms, e.g., in Ltillmann, Color Atlas of Pharmacology 2000 Thieme All rights reserved. Usage subject to terms and conditions of license. [Pg.182]

Centrally acting muscle relaxants are also widely used (baclofen, cyclobenzaprin, carisoprodol, methocarbamol, chlorphenesin, chlorzoxazone, orphenadrine, and... [Pg.209]

It is doubtful if combination drugs with centrally acting muscle relaxant substances can be given a general recommendation. Carisoprodol is me-... [Pg.497]

II. Centrally acting muscle relaxants Mephenesin Chlorzoxazone (MOBIZOX) 250 mg TDS... [Pg.111]

Bielik, N., Kocsis, P., Farkas, S. Whole-cell patch-clamp analysis of the effect of RGH-5002, a novel centrally acting muscle relaxant drug on voltage-gated sodium channels of dorsal root ganglion neurons, Naunyn Schmiedeberg s Arch. 1997, 356, Suppl 1, R25. [Pg.324]

Farkas, S., Kocsis, P., Bielik, N. Comparative characterisation of the centrally acting muscle relaxant RGH-5002 and tolperisone and of lidocaine based on their effects on rat spinal cord in vitro, Neurobiology 1997, 5, 57-58. [Pg.327]

An extensive study of Fessenden69 is concerned with biological effects of twelve pairs of carbamates (64a/64b-75a/75b) (Table 9), each pair differing by only one atom (silicon in place of carbon). The most prominent of this series is the centrally acting muscle relaxant and tranquilizer meprobamate (66a). [Pg.26]

A 73-year-old woman had rhabdomyolysis, cholestatic hepatitis, and mild renal insufficiency 14 days after she started to take the centrally acting muscle relaxant chlorzoxazone while also taking simvastatin (79). Withdrawal of the causal medication and conservative therapy with volume substitution and forced diuresis was followed by almost complete resolution of the symptoms. [Pg.550]

Kobayashi H, Hasegawa Y, Ono H. Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. EurJ Pharmacol. 1996 311 ... [Pg.177]

The centrally acting muscle relaxants have an onset of action ranging from 30 minutes to an hour. They reach their maximum concentration in the blood between 1-8... [Pg.454]

Dantrolene differs from the centrally acting muscle relaxants in that its site of action is beyond the muscle cell membrane. It interferes with the excitation-contraction coupling mechanism of striated muscle, presumably... [Pg.1048]

The centrally acting muscle relaxant guaifenesin is discussed further in Chapter 8. [Pg.290]

Centrally acting muscle relaxants depress neuron activity in the spinal cord or in the brain and are used to treat acute spasms from muscle trauma. Centrally acting muscle relaxants decrease pain, increase range of motion,... [Pg.230]

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