Methamphetamine analogs

N-substituted mescaline derivatives and methamphetamine analogs Diss. Abst. Int. 32B,5704,5706(1972). 

Pharmacology. In order to assess the importance of conformational preferences in the action of amphetamine at the adrenergic nerve endings, the effect of the amphetamine and methamphetamine analogs (NH-X,-NH-N, NM-X and NM-N) on the uptake and release of JH-norepinephrine (NE) and H-dopamine (DA) in chopped tissues from various regions of rat brain was examined. NH-X and NM-X were nearly as potent as amphetamine in the inhibition of uptake of 3H-NE into chopped cortex... 

When the methamphetamine analog MDMA is administered, selective and persistent neurochemical deficits are observed in the serotonergic terminal regions. DA is essential for these neurochemical deficits. Reducing conditions reverse these amphetamine-induced changes, providing evidence that oxidative stress is an important component in causing the neurochemical deficits. 

The most popular and, in my opinion, the best of the psychedelic amphetamines is the MDA family. This family consists of MDA, and its methamphetamine analog, XTC, or Ecstasy, or... 

Reduction of phenylacetone in the presence of methylamine rather than ammonia gives methamphetamine (53), an agent similar in action to the primary amine. Alkylation of 53 with benzyl chloride affords the analog, benzphetamine (54). ... 

This chapter discusses the responses of these extrapyramidal neuropeptide systems to the amphetamine analogs methamphetamine (METH), methylene dioxyamphetamine (MDA), and methylenedioxymethamphetamine (MDMA). These dmgs were selected for this study because they represent somewhat diverse mechanisms of action. While all three agents are able to enhance extrapyramidal serotonergic activity (Schmidt et al. 1987). only METH has been characterized as a substantial stimulant of the DA system. The effects of MDA and MDMA on extrapyramidal DA systems have not been well elucidated. Thus, evaluating and comparing the responses of the SP, NT, and Dyn extrapyramidal systems to these dmgs will help to determine the nature of the DA responses to METH, MDA, and MDMA administrations. 

This volume has focused on several amphetamine analogs in addition to amphetamine and methamphetamine, especially 3,4-methylenedioxymeth-amphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA). 

Ranaldi, R., Anderson, K.G., Carroll, F.I., Woolverton, W.L. Reinforcing and discriminative stimulus effects of RTI 111, a 3-phenyltropane analog, in rhesus monkeys interaction with methamphetamine. 

The analogs of current concern include 3,4-methylenedioxy-amphetamine (MDA) and 3,4-methylenedioxy-methamphetamine (MDMA, ecstasy, Adam, X, Stacy). 

By far the most important synthetic analog of amphetamine currently in illicit use is 3,4-methylenedioxymethamphetamine (MDMA). The formulas below show the close structural relationship of amphetamine, methamphetamine, and MDMA. 

U.S. Drug Enforcement Administration Fentanyl Analogs Phenylethylamine Analogs Methamphetamine MDMA... 

EXTENSIONS AND COMMENTARY This is one of several candidates for clinical use as a substitute for MDMA, but there will ha ve to be a much broader study of its qualitative action in man. It is clearly not psychedelic at these modest levels, and in in vitro animal studies it was apparently inactive as a serotonin releaser. The warped logic for looking at phentermine analogs was discussed in the comments that concerned MDPH. The initials used here have been chosen with care. MDM should not be used as it has found some currency as an abbreviation for MDMA (Methylene-Dioxy-Methamphetamine). MDMP fits neatly with Methylene-Dioxy-Me-Phentermine. 

The composition of the six controlled substance analogs listed above often stimulate the same areas of the brain, but are chemically quite distinct from one another. MDMA (3, 4-methylenedioxymethampheta-mine) is a complex drug that makes simple classification difficult. Its chemical structure is related both to the stimulant methamphetamine and the hallucinogen mescaline. Methamphetamine bears a close resemblance to two powerful chemicals in the body, dopamine and norepinephrine, which regulate mood, memory, and movement. 

Some designer drugs are mescaline analogs, meaning they are similar in chemical structure. The most popular mescaline analog is 3,4-methylenediozy-methamphetamine (MDMA or Ecstasy). Other analogs of mescaline include amphetamines and metham-phetamines. 

Methamphetamine Hydrochloride. Methampheta-mine, (-( )-1 -phenyl-2-methyiaminopropane hydrochloride desoxyephedrine hydrochloride (Dcsoxyn). is the N-methyl analogue of dextroamphetamine. It has more marked central and lc.ss peripheral action than dextroamphetamine. It has a very high abuse potential, and by the intravenous route, its sails are known as .speed." The overall abu.se problem presented by the drug is a national disaster. Medicinally acceptable u.scs of methamphetamine are analogous to tliose of dextroamphetamine. 

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