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Fentanyl analogs

LC-MS at present is only complementary to GC-MS. The LC-MS technique is applied for confirmations of positive results obtained by different immunochemical methods and for confirmation of the intake of drag(s). Nevertheless, the number of studies in which procedures for screening a single group of drugs, for example, benzodiazepines, amphetamines, fentanyl analogs (Fig. 16.1), and pesticides, or a subject... [Pg.310]

Figure 16.1. Screening method for fentanyl analogs in blood using LC-MS/APCI. Monitored ions [M + H]+ were chosen from full scan spectra. The blood sample was spiked with fentanyl, its three analogs and internal standard to the concentration of 5 ng/mL [6]. Figure 16.1. Screening method for fentanyl analogs in blood using LC-MS/APCI. Monitored ions [M + H]+ were chosen from full scan spectra. The blood sample was spiked with fentanyl, its three analogs and internal standard to the concentration of 5 ng/mL [6].
U.S. Drug Enforcement Administration Fentanyl Analogs Phenylethylamine Analogs Methamphetamine MDMA... [Pg.186]

Remifentanil For epidural or intrathecal administration hypersensitivity to fentanyl analogs. [Pg.882]

Analgesic efficacy and clinical use Sufentanil (Rosow, 1984 Monk et al., 1988) is a very potent fentanyl analog with analgesic and anesthetic properties and a more rapid onset and a shorter duration of action. It is used for perioperative analgesia, short duration anesthesia and as an adjunct to various anesthetic procedures including neuroleptanalgesia (Isaacson, 1992). [Pg.226]

Anyone possessing more than 40 g of fentanyl can be prosecuted for a Schedule I offense. Possession of more than 10 g of a fentanyl analog is also a Schedule I offense. The harsher penalties for fentanyl analogs are because all analogs are illegally produced in clandestine laboratories. Possessing less than 40 g of fentanyl or less than 10 g of an analog is a Schedule II offense. [Pg.204]

First-time offense violators who possess 40-399 g of fentanyl mixture can receive not less than five years or more than 40 years in prison if death or serious injury is involved, then not less than 20 years or more than life in prison. This is in addition to a fine of not more than 2 million for an individual. The same penalties apply to 10-99 g of fentanyl analog. For a second offense, the violator can receive not less than 10 years or more than life unless serious injury or death is involved. In this case, the term becomes not less than life in prison. The fine doubles to not more than 4 million for the second offense. [Pg.205]

This situation became particularly acute with respect to the development of illicit analogs of fentanyl to derive heroin substitutes. Fentanyl is a synthetic opioid, a p-receptor agonist, and is about 100-200 times more potent than morphine as an analgesic. As with other narcotic analgesics, respiratory depression is the most significant acute toxic effect of the fentanyl derivatives. Fentanyl analogs can be 80-1000... [Pg.197]

Only a few fentanyl analogs of type 12 with an R1 substituent have been reported. Three other examples are the pyridyl analogs with N-Ph of 1 replaced by 2,3, and 4-pyridyl, which had MHP ED50 values (mg/kg) 2-py, 0.14 3-py, 0.26 4-py, 4.1 fentanyl, 0.09.<36) Thus, replacement of the N-Ph of fentanyl by N-2-pyridyl has a far less adverse influence upon activity than the same replacement of 4-Ph in reversed esters of pethidine (p. 242). [Pg.295]

In further papers from Janssen Pharmaceutica an extensive series of fentanyl analogs substituted at C-4 by carboalkoxy (C02R as in pethidine), alkoxymethyl (CH2OR) and acyl (COR as in ketobemidone) were reported.<37) When alkyl in these groups was methyl, all C-4 additions were advantageous and remarkable orders of potency were achieved in rats (similar, in fact, to those found for certain bridged thebaine analgesics, p. 69) as shown (13-15). [Pg.296]

Illicit fentanyl derivatives act as agonists at the opioid receptor. Unsuspecting heroin users typically administer their usual dose of heroin, and receive variable amounts of the more potent fentanyl analog. These agents produce profound central nervous system and respiratory depression through mechanisms common to other opioids. [Pg.1135]

ME Alburges, et al. Fentanyl receptor assay—Development of a radioreceptor assay for analysis of fentanyl and fentanyl analogs in urine. J Anal Toxicol 15 311, 1991. [Pg.305]


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