Metabolism chemistry

A quote from a biochemistry text IS instructive here This IS not an easy reaction in or game chemistry It is how ever a very important type of reaction in metabolic chemistry and is an integral step in the oxidation of car bohydrates fats and several ammo acids G L Zubay Biochemistry 4th ed William C Brown Publishers 1996 p 333... 

Major metabolic chemistry leading to long-life but unstable polymers... 

The isolation of the chemicals within the protocell causes a specific problem. Once the reactions have reached the extent of equilibrium allowed, limited by composition, all chemistry stops until the protocell dries out or brings in new molecules. The drying mechanism could certainly replenish the metabolism, requiring the protocell to dry out in a localised region on a substrate and re-form. The protocell would gain some new molecules and lose some old molecules in the process. The cell metabolism chemistry will only continue away from the surface and in a fully independent way when the membrane transport problem is solved. 

Casida JE, Ruzo LO (1980) Metabolic chemistry of pyrethroid insecticides. Pestic Sci 11 257-269... 

Metabolic chemistry is characterized by functionality. Each reaction is important because of its participation in a sequence of reactions, and each sequence interacts functionally with other sequences. 

The metabolism of triazine herbicides in plants has been diligently studied since their introduction. Much of what is currently known about the metabolic pathways was obtained only after newer and more advanced methods of chromatography and spectral analysis were discovered. The study of triazine herbicides has resulted in improved methodologies and understanding of plant proteins, biochemistry, and metabolic pathways. These pathways will serve as a reference point for future researchers in their quest for a complete understanding of plant metabolic chemistry. 

We know very little about the secondary metabolic chemistry of the plankton. Studies of the meroplankton, specifically of the pelagic eggs, embryos, and larvae of benthic invertebrates, have... 

These concepts and definitions provide the vocabulary and theoretical framework for much of the analysis that follows, as we explore one of the most interesting and important aspects of life, the evolution and regulation of the internal milieu. We begin this exploration by considering a primary way in which life depends on water, namely, the role of water as a reactant in metabolic chemistry. 

Electron Transfer Chain, Chemistry of Metabolic Diseases, Chemical Biology of Mitochondria, Structural Dynamics of Mitochondrial Proteomics Oxidative Metabolism, Chemistry of... 

Testa, Bernard, and Joachim M. Mayer. Hydrolysis in Drug and Prodrug Metabolism Chemistry, Biochemistry, and Enzymology. Cambridge, U.K. Wiley-VCH, 2003. 

Testa, B. and Mayer, J.M. (2003) Hydrolysis in Drug and Prodrug Metabolism -Chemistry, Biochemistry and Enzymology, Wiley-VHCA, Zurich. 

The value of obtaining multiple datasets from various biofluid samples and tissues of the same animals collected at different time points has been demonstrated. This procedure has been termed integrated metabonomics [2] and can be used to describe the changes in metabolic chemistry in different body compartments affected by exposure to toxic drugs. An illustration of the types of information that can be obtained is shown in Figure 13.3-6, from an NMR spectroscopic study of the acute toxicity of a-naphthylisothiocyanate, a model liver toxin [53]. Such timed profiles in multiple compartments are characteristic of particular types and mechanisms of pathology and can be used to give a more complete description of the biochemical consequences than can be obtained from one fluid or tissue alone [54]. 

All ars operons encode an ArsC arsenate reductase enzyme. However, as mentioned above, there are two sequence-unrelated families of arsenate reductases whose role is to reduce less toxic As(V) to more toxic As(lll) (21,34,36). It is only As(lll) and not As(V) that is pumped out from the cells by the ArsB transport protein. It seems counterintuitive from an environmental biology or metabolic chemistry point of view to convert a less toxic compound to a more toxic form. We have speculated that arsenite pumping activity evolved prior to the existence of oxygen in the atmosphere, and ArsC evolved only after an oxidizing atmosphere developed (8). At that point arsenite would spontaneously oxidize to arsenate, presenting a selective pressure for evolution of a reductase. The two types of arsC genes are positioned last in all ars operons shown in Fig. 2. The... 

The discipline of pesticide metabolism chemistry, as well as other disciplines involved in the toxicological evaluation of pesticides, will no doubt be required to become even more responsive to pesticide regulatory agencies in the future. 

Although the electron-rich thiophene may lead to toxicity, the metabolic chemistry of thiophene can also lead to desirable therapeutic effects as in the case of clopidogrel (Plavix). The parent compound is oxidized by cytochrome P-450, and further oxidation in the presence of water... 

The utilization of H2 in metabolic chemistry has remained a common thread throughout the long history of microbial evolution. The increasing complexity of individual organisms and microbial ecosystems has been mirrored by an increasing complexity in the role played by H2. Successive biochemical advances have often retained and expanded on earlier aspects of H2 metabolism. This continuity and expansion in the microbial utilization of H2 corresponds to a continually evolving role for H2 in the biogeochemistry of the Earth. 

Research interests include chemistry of vegetable tannins the shikimate pathway metabolic chemistry. 

Behall, K Reiser, S. Effects of pectin on human metabolism. Chemistry and funetions of pectins. Washington, DC American Chemical Society, p. 248-265, 1986. 

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