Menstrual irregularities

Endocrine system—menstrual irregularities, hyperglycemia, and decreased growth in children and... 

Amenorrhea, other menstrual irregularities, development of cushingoid state, suppression of growth in children, secondary adrenocortical and pituitary unresponsive (particularly in times of stress), decreased carbohydrate tolerance, manifestation of latent diabetes mellitus, increased requirements for insulin or oral hypoglycemic agents (in diabetics)... 

In women receiving an androgen preparation for breast carcinoma, the most common adverse reactions are amenorrhea, other menstrual irregularities, and virilization (acquisition of male sexual characteristics by a woman). Virilization produces facial hair, a deepening of the voice, and enlargement of the clitoris. Male pattern baldness and acne may also be seen. 

Hot flushes, nausea, vomiting, vaginal bleeding, vaginal discharge, menstrual irregularities, skin rash... 

CF patients often experience delayed puberty. In females, menarche occurs 18 months later than average, and menstrual irregularity is common. Females also have reduced fertility due to increased viscosity of cervical mucus. Due to increasing life expectancy, pregnancy is becoming more common however, outcomes depend on pre-partum nutritional and pulmonary status. 

Cushing s disease and adrenal carcinomas cause adrenal androgen hypersecretion in high enough concentrations to result in signs of androgen excess (such as acne, menstrual irregularities, and hirsutism) and cause virilization in women.4... 

Menstrual irregularities (the most typical presentation is amenorrhea) (70%)... 

Androgens Fluoxymesterone 10 mg orally twice a day Deepening voice, alopecia, hirsutism, facial/truncal acne, fluid retention, menstrual irregularities, cholestatic jaundice... 

Patients with secondary hypertension may complain of symptoms suggestive of the underlying disorder. Patients with pheochromocytoma may have a history of paroxysmal headaches, sweating, tachycardia, palpitations, and orthostatic hypotension. In primary aldosteronism, hypokalemic symptoms of muscle cramps and weakness may be present. Patients with hypertension secondary to Cushing s syndrome may complain of weight gain, polyuria, edema, menstrual irregularities, recurrent acne, or muscular weakness. 

The most frequent adverse effect of DMPA is menstrual irregularities, which decrease after the first year. Breast tenderness, weight gain, and depression occur less frequently. 

Antipsychotic-induced elevations in prolactin levels with associated galactorrhea and menstrual irregularities are common. These effects may be dose related and are more common with the use of FGAs and risperidone. 

Spironolactone may induce painful gynecomastia and impotence in the male, and menstrual irregularities in the female. 

Tics Tardive dyskinesia Akathisia Menstrual irregularities Breast enlargement Depression ( )... 

Emergency contraceptives The most common adverse events in the clinical trial for women receiving emergency contraceptives include nausea abdominal pain/cramps fatigue headache menstrual irregularities dizziness breast tenderness vomiting diarrhea. 

Common (at least 3%) adverse reactions include menstrual irregularities weight changes headache nervousness abdominal pain discomfort asthenia dizziness. 

Virilization Observe women for signs of virilization (deepening voice, hirsutism, acne, clitoromegaly, and menstrual irregularities). Discontinue therapy at the time of evidence of mild virilism to prevent irreversible virilization. 

Females - Amenorrhea and other menstrual irregularities inhibition of gonadotropin secretion and virilization, including deepening voice and clitoral enlargement. 

GU Changes in libido incontinence menstrual irregularities urinary retention. Ophthalmic Diplopia nystagmus visual disturbances. 

GU Gynecomastia and testicular swelling in the male breast enlargement, menstrual irregularity and galactorrhea in the female increased or decreased libido painful ejaculation impotence nocturia urinary frequency. 

Miscellaneous Anxiety depression dizziness headache rash abdominal pain/discomfort gingival disorder infectious diarrhea nausea rectal pain/discomfort tooth disorder vomiting arthritis back pain myalgia lower extremity pain menstrual irregularity vaginitis influenza upper/lower respiratory tract infection fatigue otitis sleep disorder urinary tract infection. 

Fertility Impairment Menstrual irregularities were observed in monkeys administered interferon beta-la at a dose 100 times the recommended weekly human dose. Pregnancy Category C. 

Excessive dosage produces signs and symptoms of hyperthyroidism, including weight loss, palpitations, increased appetite, tremors, nervousness, tachycardia, hypertension, headache, insomnia, and menstrual irregularities,... 

The common side effects are drowsiness, lethargy, ataxia. They also cause behavioural changes and dose dependent impairment of visual motor coordination. Other side effects which occur rarely are vertigo, headache, allergy, photosensitization, leucopenia, impaired sexual function and menstrual irregularities. 

Minor side effects include drowsiness confusion, gastrointestinal upset, gynaecomastia and menstrual irregularities. 

Adverse effects include hot flushes, vaginal bleeding, menstrual irregularities, anorexia, depression and dermatitis. 

Adverse effects include menstrual irregularities, deepening of voice in women, edema, cholestatic jaundice, virilization, priapism, increased libido, acne, precocious puberty, premature epiphyseal closure, gynaecomastia and hepatic carcinoma and reduction in spermatogenesis. 

They are usually given by IM route. They lead to higher incidence of menstrual irregularities and amenorrhoea. 

Adverse effects include nausea, vomiting, hot flushes, vaginal bleeding, pruritus vulvae and menstrual irregularities. 

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