Memory disruption

Anesthetic techniques that have minimized adverse effects include the use of muscle relaxants and, more recently, nerve stimulators to assess adequacy of relaxation, the introduction of very rapid acting, short-duration barbiturates, and the use of atropinic agents to minimize the cardiovascular response to a combination of a seizure and anesthesia (93). In addition, 100% oxygenation (adequacy monitored by a pulse oximeter) with positive-pressure ventilation can minimize related cardiac events and memory disruption. 

Molecules A and B were synthesized in order to compare their eventual activity against cerebral dysfunction, namely, memory disruption, with that of reference compound piracetam. Tested on mice, pyrrolizidine (A) delays this dysfunction better than piracetam (27.8% versus 21.7%). The ethylenediamine derivative (B) behaves similarly.501... 

In human prefrontal patients, a striking experimental demonstration of working memory disruption due to dorsolateral damage is the Wisconsin Card sorting Test, here described by Dudai ... 

Deadwyler SA, Heyser CJ, Hampson RE (1995) Complete adaptation to the memory disruptive effects of delta-9-THC following 35 days of exposure. Neurosci Res Commun 17 9-18... 

Complex partial seizures manifest themselves as bizarre behaviours which are also known as psychomotor or temporal lobe epilepsy, since a lesion (focus) is often found in that brain area. Repetitive and apparently purposeful movements vary from simple hand clenching or rubbing to more bizarre hand movements and walking. These can last a few minutes, often disrupt other ongoing activity or speech and the patient has no subsequent memory of them. Complex seizures may develop from simple ones. 

Even if there is a link between the presence of tangles and plaques and the emergence of AzD, it is by no means certain how those markers could be responsible for all the symptoms. They do not seem to be sufficiently numerous or widely spread to disrupt brain function to the extent that eventually occurs in AzD, although their preferential location in the hippocampus and the known association of that area with memory processing could explain the loss of that faculty. 

It has been known for many years that antimuscarinic drugs like hyoscine, which enter the brain, cause amnesia when used clinically, e.g. pre-operatively, to reduce bronchial secretions. In experimental studies in both humans and animals they disrupt both the acquisition and the performance of learned behaviour. Anti-cholinestrase drugs have the opposite effect. It is by no means certain, however, that the memory defects induced by antimuscarinics are identical to those seen in AzD. 

AR is the most common atopic disease in the United States. It affects between 9% and 24% of adults and up to 42% of children.2,3 More than 80 million Americans experience 7 or more days of nasal-ocular symptoms annually as a result of AR.3 Additionally, AR is responsible for 3.5 million lost work days and 2 million missed school days annually in the United States.4 In addition to decreased quality of life from AR symptoms, patients also suffer from disrupted sleep, resulting in fatigue, irritability, memory deficits, excessive daytime somnolence, and depression that further reduce quality of life.5... 

There is a significant amount of data from other countries on the effects on human health of large-scale pesticide production and use, in particular of OPPs and OCPs. Even one-time, accidental contact with some OCPs and OPPs such as dieldrin, malathion, and parathion, can lead to changes in the encephalogram (which remain for a year after exposure), disruptions of sleep patterns and memory, loss of libido, and difficulties in concentration [3]. Global practice shows that all pesticides are toxic to humans. 

Most displayed decreased blood cholinesterase activity. Many were observed to have affective syndromes (anxiety, fear, aggression), sometimes accompanied by symptoms of depression. Disruption of memory was noted. Vision problems are also caused by long-term contact with OPPs [A64]. In cotton growing regions with intensive OPP use, the number of spontaneous miscarriages and stillbirths was higher than elsewhere [3]. 

Apart from this paradoxical exception, it is clear that at higher doses alcohol intoxication is associated with impaired performance across a range of tasks involving psychomotor, attentional and memory processing. At moderate to high doses, alcohol impairs the formation of new memories and disrupts working memory. However, established memory is left relatively unimpaired, suggesting that... 

Studies reveal that a homozygous GlyT-1 (-/-) knockout in mice is neonatally lethal. However heterozygous GlyT-1 (+/-) mice survive to adulthood and display enhanced NMDA receptor function in the hippocampus, better memory retention, and no disruption in sensory gating when dosed with amphetamine [15]. 

Adenylyl cyclase in learning and memory. The cAMP-signal transduction cascade has been demonstrated to play a role critical to the formation of long-term memory in both cellular models and in animals. The specific adenylyl cyclases involved are being identified by current research. In AC1 mutant mice there is a partial disruption of long-term potentiation (LTP), a cellular model of... 

Dissociation is the core feature of the dissociative disorders it is defined by the DSM-IV as a disruption in the usually integrated functions of consciousness, memory, identity, or perception of the environment (American Psychiatric Association, 1994, p. 477). Dissociation is usually assessed as a continuum, most often using the Dissociative Experiences Scale (DES Bemstein-Carlson Putnam, 1986), a 28-item self-report measure. The DES items are rated on a scale reflecting the frequency of dissociative experiences (O-to-100% in 10% intervals). Factor analyses of DES items have led to the development of three subscales (Carlson et al., 1993 Frischholz, Braun, Sachs, Schwartz, 1991 Ross, Joshi, Currie, 1991). They are (a) Absorption, which reflects dissociation from surroundings (e.g., daydreaming) (b) Amnesia, which reflects dissociation from past experiences and (c) Depersonalization-Derealization, which reflects dissociation from the body or senses. 

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