Megestrol

Megestrol acetate can be recrystakhed from aqueous methanol (108). It is soluble in acetone, chloroform, and ethanol slightly soluble in ether and fixed oils and insoluble in water (107). Additional spectral and physical data have been pubHshed (62). [Pg.217]

Megestrol acetate (79) is stmcturaHy related to progesterone (1). It has been prepared from medroxyprogesterone acetate (74) by chloranil-mediated dehydrogenation. It also has been prepared from hydroxyprogesterone acetate (42) via 6-methylenation and double-bond migration (109,110). [Pg.217]

Noncontraceptive Uses of Progestins. Progestins have other therapeutic uses aside from contraception. Hormone-dependent tumors and cysts involving reproductive tissues respond to progestins. Megestrol acetate and MPA are the two most commonly used progestins to treat breast cancer... [Pg.223]

In addition to the sex hormones and corticosteroids, other steroid dmgs have substantial worldwide markets. For example, cytostatic hormones had worldwide sales of approximately 1.8 biUion in 1994. Included in these 1.8 biUion are several steroids or steroid-mimetics such as megestrol acetate and tamoxifen (282), respectively (262). [Pg.448]

The pregnanes include megestrol, medroxyprogesterone acetate [71-58-9] C24H34O4 (6), chlormadinone acetate [302-22-7] C23H2QCIO4, and cyproterone acetate [427-51-0], C24H2gC104 (7). [Pg.116]

Medroxyprogesterone Acetate Megestrol Acetate Melengestrol Acetate Norethindrone Pregnenolone Acetate Progesterone... [Pg.445]

Acetoxolone aluminum salt Aluminum amalgam Dinoprostone Aluminum tert-butoxide Megestrol acetate Aluminum chloride Acebutolol... [Pg.1611]

Mepenzolate bromide Pipenzolate bromide Pipoxolan HCI Benzoic anhydride Flavoxate HCI Benzonitrile Fentiazac Benzophenone Diphenidol Phenytoin 1,4-Benzoaquinone Dobesilate calcium Ethamsylate Megestrol acetate Benzotetronic acid... [Pg.1615]

Mindiab - Glipizide Minias - Lormetazepam Minibetic - Glipizide Minigest - Megestrol acetate Minihep - Heparin... [Pg.1718]

Glucocorticoids have inhibitory (apoptotic) effects on lymphocyte proliferation and are used to treat leukemias and lymphomas. Estrogens (fosfestrol) are used to block the effect of androgens in prostate cancer. Progestogens (megestrol, medroxyprogesteroneacetate) have been useful for treating endometrial carcinoma, renal tumors, and breast cancer. [Pg.155]

Bicalutamide may increase the effect of oral anticoagulants. Flutamide enhances the action of leuprolide. Additive antineoplastic effects may occur when leuprolide is administered with megestrol or flutamide. Estrogens decrease the effectiveness of tamoxifen. [Pg.593]

Discontinue estrogen-containing products and megestrol based on clinical judgement... [Pg.48]

Megestrol acetate—has glucocorticoid-like activity ° Mifepristone (RU 486)—antagonizes glucocorticoid receptors... [Pg.687]

Other drugs with glucocorticoid activity (e.g., megestrol acetate, medroxyprogesterone)... [Pg.693]

A number of non-hormonal therapies have been studied for symptomatic management of vasomotor symptoms, including antidepressants [e.g., selective serotonin reuptake inhibitors (SSRIs) and venlafaxine], herbal products (e.g., soy, black cohosh, and dong quai), and a group of miscellaneous agents (e.g., gabapentin, clonidine, and megestrol). The choice of therapy depends on the patient s concomitant disease states, such as depression and hypertension, and the risk for potential adverse effects. [Pg.774]

Megestrol RCT in breast cancer patients demonstrating up to 80% reduction in hot flashes 20-40 mg daily Vaginal bleeding, headache, weight gain, thromboembolism, edema... [Pg.775]

Megestrol is a synthetic progestin with antiestrogen properties that is used for breast cancer and in higher doses for weight... [Pg.1296]

See also in sourсe #XX -- [ Pg.15 ]

See also in sourсe #XX -- [ Pg.375 , Pg.409 ]

See also in sourсe #XX -- [ Pg.447 , Pg.577 ]

See also in sourсe #XX -- [ Pg.720 ]

See also in sourсe #XX -- [ Pg.165 , Pg.167 , Pg.168 ]

See also in sourсe #XX -- [ Pg.304 ]

See also in sourсe #XX -- [ Pg.830 ]

See also in sourсe #XX -- [ Pg.146 ]

See also in sourсe #XX -- [ Pg.269 , Pg.280 ]

See also in sourсe #XX -- [ Pg.331 ]

See also in sourсe #XX -- [ Pg.55 ]

See also in sourсe #XX -- [ Pg.375 , Pg.389 ]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...