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Megestrol acetate adverse effects

Megestrol acetate has also proved of value in patients with metastatic prostatic cancer, epithelial ovarian cancer, or malignant melanoma and is therefore used in both sexes. The adverse effects are very similar in men to those seen with oncological doses in women loss of libido and potency is likely to occur in male patients. In one clinical study of 43 men with recurrent and metastatic cancer of the prostate given megestrol acetate 160 mg/ day orally, five developed a symptomatic rise in liver... [Pg.290]

When megestrol acetate was used alongside diethylstil-bestrol or ethinylestradiol in men with previously untreated metastatic carcinoma of the prostate, there was a high incidence of feminizing adverse effects (70-74%), no doubt attributable to the estrogens a higher than expected rate of cardiovascular complications (18%) and an unexplained need for cortisone replacement (13%) were also observed (12). [Pg.290]


See other pages where Megestrol acetate adverse effects is mentioned: [Pg.405]    [Pg.289]    [Pg.290]    [Pg.405]    [Pg.2931]    [Pg.2932]    [Pg.2932]    [Pg.1501]    [Pg.2533]    [Pg.425]   
See also in sourсe #XX -- [ Pg.693 , Pg.775 , Pg.1297 , Pg.1317 , Pg.1318 ]

See also in sourсe #XX -- [ Pg.2313 ]




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