Progestin synthetic

Progesterone is secreted by the corpus luteum, placenta, and in small amounts by the adrenal cortex. Progesterone and its derivatives (ie, the progestins) transform the proliferative endometrium into a secretory endometrium. Progestins are necessary for the development of the placenta and inhibit the secretion of pituitary gonadotropins, which in turn prevents maturation of the ovarian follicle and ovulation. The synthetic progestins are usually preferred for medical use because of the decreased effectiveness of progesterone when administered orally. 

Megestrol is a synthetic progestin with antiestrogen properties that is used for breast cancer and in higher doses for weight... 

Hormonal contraceptives contain either a combination of synthetic estrogen and synthetic progestin or a progestin alone. 

In 1992, the US FDA approved a long-acting contraceptive device containing synthetic progestin medroxyprogesterone acetate (MPA) hormones. Manufactured by Pfizer, Inc., it is sold under the trade name Depo-Provera . It is typically injected into a woman s buttocks or upper arm, and renders her temporarily sterile for up to 3 months. ... 

One of the most important areas of synthetic estrogens and progestins are their use as oral contraceptives, for hormone replacement therapy, and as drugs for menstrual disorders. 

A second chemical class of synthetic progestins contains the pregnane nucleus structure of progesterone along with some additional substitutions. Alkyl chain additions to the C17 position increase the biological... 

Several progestins are used in combination products. Norgestrel (Ovrette) is a mixture of active and inactive enantiomers levonorgestrel (Norplant) is the active enantiomer. Levonorgestrel and norethindrone are the most potent synthetic progestins in oral contraceptive preparations. 

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