Megestrol Aminoglutethimide

Carcinoma of breast (1) Adjuvant chemotherapy or tamoxifen after primary breast surgery Cyclophosphamide, doxorubicin, vincristine, methotrexate, fluorouracil, paclitaxel, mitoxantrone, prednisone, megestrol, androgens,1 aminoglutethimide, trastuzumab... 

Cytadren - aminoglutethimide Megace - megestrol acetate Thalomid - Thalidomide... 

Aminoglutethimide 250 mg four times daily reduced the serum levels of megestrol 160 mg daily by 78% in 6 postmenopausal women. ... 

Both interactions appear to be established and are possibly clinically important. A 50% reduction in the plasma levels of medroxyprogesterone and megestrol should be expected during concurrent use, and this may reduce the adrenal suppressive effect. The authors of one report say that to achieve adequate plasma medroxyprogesterone acetate levels in breast cancer (above 100 nanograms/mL) a daily dose of 800 mg of Provera is probably necessary in the presence of aminoglutethimide 125 or 250 mg twice daily. This is double the usual recommended dose for this condition. 

Lundgren S, Lonnii PE, / vaag A, Kvinnsland Influence of aminoglutethimide on the metabolism of medroj prc esterone acetate and megestrol acetate in postmenopausal patients with advanced breast cancer. Cancer Chemoffier Pharmacol (1990) 27,101-5. 

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