Meclofenamic acid

Ullman condensation of m-trifluoromethylaniline (13) with o-iodobenzoic acid in the presence of copper-bronze affords flu-fenamic acid (14). An analogous reaction of o-chlorobenzolc acid with 2,3-dimethylaniline (15) gives mefenamic acid (16) meclofenamic acid (18) is obtained by Ullman condensation employing 2,6-dlchloro-3-methylaniline (17). 

Ethyl 5-methyl isoxazole-3-carbamate Sulfamethoxazole N-Ethylmorpholine Meclofenamic acid... 

MAO, see monoamine oxidase Marihuana, 394 Mary Jane, 394 Mebrohydroline, 319 Mebrophenhydramine, 44 Mebutamate, 218 Meclastine, 44 Meclizine, 59 Meclofenamic acid, 110 Medazepam, 368 Medrogestone, 182, 183 Medroxyprogesterone acetate, 180, 186, 188 Medrylamine, 41 Mefenamic acid, 110 Mefruside, 134 Megesterol acetate, 180 Melengesterol acetate, 182, 183, 187... 

MAO, see monoamine oxidase Maprotiline, 220, 221 Mazindol, 462 Mebendazole, 353 Mebeverine, 54 MeCCNU, 12 Meclocgcline, 227 Meclofenamic acid, 88 Medibazine, 30 Mediquox, 390 Medroxyprogesterone... 

Meclofenamic acid Meclofenamic acid, iV-(2,6-dichloro-m-tolyl)anthranylic acid (3.2.20), is synthesized analogous to flufenamic acid, by the reaction of potassium salt of 2-bromobenzoic acid with 2,6-dichloro-3-methylaniline in the presence of copper (11) bromide in a mixture of iV-ethylmorpholine and diglyme [82,83]. 

Lee, Y. T. and Wang, Q. Inhibition ofhKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid, Eur. J. Pharmacol. 1999, 378, 349-356. 

Figure 92 Meclofenamic acid photochemical-induced dechlorination.

Aromatic dechlorination under light is also observed for the API meclofenamic acid (135). Meclofenamic acid undergoes photochemical dechlorination and ring closure to carbazole products (Fig. 92). 

A GS-MS method for the analysis of etodolac in human plasma has been developed [16]. Plasma samples were spiked with meclofenamic acid (the internal standard), acidified with 5N HC1, and extracted twice with chloroform / dichloromethane / hexane (50 25 25, v/v). The organic phase was evaporated, the residue methylated with ethereal diazomethane, dried again, and reconstituted in hexane. Analytical separation was performed on a 15 m x 0.24 mm i.d., 0.25 pm film thickness, fused silica capillary column. The oven temperature was variable (150 to 260°C) and the injector was at 260°C. The carrier gas was helium at 1 mL/min. Mass spectra were obtained using positive electron impact ionization (70 eV) at m/z 228 for etodolac. The method was linear in the 1-10 ng/mL (low) and 10-100 ng/mL (high) concentration range. The detection limit was 0.5 ng/mL in plasma, and recovery of etodolac from plasma sample exceeded 92%. 

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