Meclofenamic acid, therapeutic

The therapeutic index of meclofenamic acid in horses is not well defined. For example, ponies treated with meclofenamic acid at the recommended dosage (2.2mg/kg) for 10 days had decreased plasma protein concentrations but no... 

Snow D H, Baxter R Whiting B 1981 The pharmacokinetics of meclofenamic acid in the horse. Journai of Veterinary Pharmacoiogy and Therapeutics 4 147-156 Soma L R, Gailis D E, Davis W L et ai 1983 Phenylbutazone kinetics and metabolic concentrations in the horse after five days of administration. American Journai of Veterinary Research 44 2104-2109 Soma L R, Behrend E N, Rudy J A et al 1988 Disposition and excretion of fiunixin meglumine in horses. American Journal of Veterinary Research 49 1894-1898 Soraci A, Benoit E, Jaussaud P et al 1995 Enantioselective glucuronidation and subsequent biliary excretion of carprofen in horses. American Journal of Veterinary Research 56 358-361... 

Snow, D.H., Baxter, P. Whiting, B. (1981) The pharmacokinetics of meclofenamic acid in the horse. Journal of Veterinary Pharmacology and Therapeutics, 4, 147-156. 

Mefenamic acid has central and peripheral actions, and meclofenamic acid may antagonize directly certain effects of prostaglandins, although it is not clear that receptor blockade is attained at therapeutic concentrations. 

In another study, the "fenamates" were shown to antagonize the response of human isolated bronchial muscle to SBS-A and PGF2a> particularly the latter. Meclofenamate (XI) was more active than flufenamlc acid (XIV) and both were more active than phenylbutazone or aspirin. Evaluation of flufenamlc acid in partially refractory asthmatics failed to reveal any significant beneficial therapeutic effect. ... 

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