Matrix-assisted laser desorption ionization time of flight mass spectroscopy

Considering these situations, the observation of molecular weights, particularly by matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MASS), is essential [33]. The operation is simple and enables us to observe the molecular ion peaks of CPOs with molecular weights exceeding 10,000. The quahty of the measurement is strongly dependent on the choice of the matrix. Therefore, the search for the best matrix for each CPO should be pursued. 

Wang, Z. Russon, L. Li, L. Roser, D. C. Long, S. R. Investigation of spectral reproducibility in direct analysis of bacteria proteins by matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy. Rapid Comm. Mass Spectrom. 1998,12,456-464. 

SEC, size exclusion chromatography. MALDI-TOF-MS, matrix-assisted laser desorption/ ionization time-of-flight mass spectroscopy. 

T. Yamagaki, Y. Ishizuka, S.-I. Kawahara, H. Nakanishi. Analysis of glycosidic linkages in saccharide compounds by post-source decay fragment methods in matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy. Rap. Comm. Mass. Spec. 1999, /1,527-531. 

For high-throughput screening of SNPs, techniques such as MALDI-TOF-MS (matrix-assisted laser desorption-ionization time-of-flight mass spectroscopy) are used. Examples of projects are population studies/gene diagnostics, clinical studies, analysis of mitochondrial DNA or Y- chromosomal SNPs, and DNA forensics. The... 

Matrix assisted laser desorption ionization-time of flight mass spectroscopy (MALDI-TOF MS) has proven to be a powerful tool for analysis of many biopolymers, such as proteins, oligonucleotides, and polysaccharides. Recently, it has been used to characterize many synthetic polymers [174]. Another... 

Such a procedure yielded pentaerythritol-/ /M tetraester with an average MW of 4.5-4.9 kDa according to H-NMR and gel permeation chromatography (GPC) analyses (25). Matrix-assisted laser desorption ionization-time of flight-mass spectroscopy, or MALDI-TOF-MS, and C-NMR confirmed the NMR-and GPC-derived molecular structure and composition of the product (25). Esterification of the polyol acyl acceptor s hydroxyl groups occurred at 78%,... 

---