Matrix-assisted laser desorption/ionization sourc

Loboda A.V., Krutchinsky A.N., Bromisrski M., Ens W., and Standing K.G. (2000), A tandem quadrupole/time of flight mass spectrometer with a matrix-assisted laser desorption/ionization source design and performance, Rapid Commun. Mass Spectrom. 14, 1047-1057. 

In 1974, Comarisov and Marshall60 developed Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS). This technique allows mass spectrometric measurements at ultrahigh mass resolution (R = 100000-1000000), which is higher than that of any other type of mass spectrometer and has the highest mass accuracy at attomole detection limits. FTICR-MS is applied today together with soft ionization techniques, such as nano ESI (electrospray ionization) or MALDI (matrix assisted laser/desorption ionization) sources. 

Hatsis, P., Brombacher, S., Corr, J., Kovarik, P., and Volmer, D. A. (2003). Quantitative analysis of small pharmaceutical drugs using a high repetition rate laser matrix-assisted laser/ desorption ionization source. Rapid Commun. Mass Spectrom. 17 2303-2309. 

Matrix Assisted Laser Desorption/Ionization Source... 

FiCURE 4.3 Matrix-assisted laser desorption ionization source, (a) Gas phase ions are formed when the nitrogen laser produces photons at 337 nm that strike the solid matrix-analyte sample. The ions above the sample plate are accelerated to 25,000 eV of kinetic energy and fly through a stainless steel tube (not shown) for TOP m/z analysis, (b) Three commonly used matrix molecules for MALDI of peptides and proteins. 

Loboda, A.V. Krutchinsky, A.N. Bromirski, M. Ens, W. Standing, K.G. A tandem qua-drupole/time-of-liightmass spectrometer with a matrix-assisted laser desorption/ionization source Design and performance. Rapid Commun. Mass Spectwm. 2000,14,1047-1057. 

Kovarik P, Grivet C, Bourgogne E, Hopfgartner G. Method development aspects for the quantitation of pharmaceutical compounds in human plasma with a matrix-assisted laser desorption/ionization source in the multiple reaction monitoring mode. Rapid Commun Mass Spectrom 2007 21(6) 911—919. 

Pribil, P.A., Patton, E., Black, G., Dorosheriko, V. and Fenselau, C., Rapid characterization of Bacillus spores targeting species-unique peptides produced with an atmospheric pressure matrix-assisted laser desorption/ionization source. J. Mass Spectrom., 40, 464—474 (2005). 

---