Matrix-assisted laser desorption/ionization delayed extraction

JENSEN, O.N., PODTELEJNKOV, A., MATTHIAS-MANN, M., Delayed extraction improves specificity in database searches by matrix-assisted laser desorption/ionization peptide maps, Rapid Comm. Mass Spectrom., 1996,10, 1371-1378. 

DGE a AC AMS APCI API AP-MALDI APPI ASAP BIRD c CAD CE CF CF-FAB Cl CID cw CZE Da DAPCI DART DC DE DESI DIOS DTIMS EC ECD El ELDI EM ESI ETD eV f FAB FAIMS FD FI FT FTICR two-dimensional gel electrophoresis atto, 10 18 alternating current accelerator mass spectrometry atmospheric pressure chemical ionization atmospheric pressure ionization atmospheric pressure matrix-assisted laser desorption/ionization atmospheric pressure photoionization atmospheric-pressure solids analysis probe blackbody infrared radiative dissociation centi, 10-2 collision-activated dissociation capillary electrophoresis continuous flow continuous flow fast atom bombardment chemical ionization collision-induced dissociation continuous wave capillary zone electrophoresis dalton desorption atmospheric pressure chemical ionization direct analysis in real time direct current delayed extraction desorption electrospray ionization desorption/ionization on silicon drift tube ion mobility spectrometry electrochromatography electron capture dissociation electron ionization electrospray-assisted laser desorption/ionization electron multiplier electrospray ionization electron transfer dissociation electron volt femto, 1CT15 fast atom bombardment field asymmetric waveform ion mobility spectrometry field desorption field ionization Fourier transform Fourier transform ion cyclotron resonance... 

Vestal M.L., Juhasz P., and Martin S.A. (1995), Delayed extraction matrix assisted laser desorption/ionization time of flight mass spectrometry, Rapid Commun. Mass Spectrom. 9, 1044—1050. 

Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer with UV laser (i.e., 337-nm nitrogen laser), MALDI probe, and optional delayed extraction and postsource decay... 

Figure 5-5. A. MALDI mass spectrum of the anthocyanin pigments in the grape variety Marechal Foch. This figure is from the article Matrix-assisted laser desorption ionization mass spectrometry analysis of grape anthocyanins , Am. J. Enol. Vitic. 50 199-203 by Sugui, J. A., Wood, K. V., Yang, Z., Bonham, C. C. and Nicholson, R. L. 1999. Reprinted by permission of the American Society for Enology and Viticulture. B. MALDI mass spectrum of grape anthocyanins acquired on a MALDI mass spectrometer with delayed extraction capabilities. Peak identities are discussed in the text.

E. Sugiyama, A. Hara, and K. Uemura, A quantitative analysis of serum sulfatide by matrix-assisted laser desorption ionization time-of-flight mass spectrometry with delayed ion extraction, Anal. Biochem., 274 (1999) 90-97. 

Kaufmann R, Chaurand P, Kirsch D, Spengler B. Post-source decay and delayed extraction in matrix-assisted laser desorption/ionization-reflectron time-of-flight mass spectrometry. Are there trade-offs . Rapid Commun Mass Spectrom 1996 10 1199-1208. 

Mowat, I. A., Donovan, R. J., and Maier, R. R. J., Enhanced Gationization of Polymers Using Delayed Ion Extraction with Matrix-Assisted Laser Desorption/ Ionization, Rapid Comm. Mass. Spectrom., 11, 89, 1997. 

Vitalini, D., Mineo, R, and Scamjxjrrino, E., Effect of Combined Changes in Delayed Extraction and Potential Gradient on the Mass Resolution and Ion Discrimination in the Analysis of Polydisperse Poymers and Polymer Blends by Delayed Extraction Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry, Rapid Comm. Mass. Spectrom., 13, 2511,1999. 

Kaufmann, R., Chaurand, R, Kirsch, D., and Spengler, B., Post-source Decay and Delayed Extraction in Matrix-assisted Laser Desorption/Ionization-Reflectron Time-of-Flight Mass Spectrometry. Are There Trade-offs , Rapid Comm. Mass. Spectrom., 10, 1199, 1996. 

Linnemayr, K., Vana, P, and AUmaier, G., lime-delayed Extraction Matrix-assisted Laser Desorption Ionization lime-of-flight Mass Spectrometry of Poly-acrylnitrile and Other S3mthetic Polymers with the Matrix 4-Hydroxyben-zylidene Malononitrile, Rapid Comm. Mass Spectrom., 12,1344, 1998. 

Zhang W, Niu S, Chait BT. Exploring infrared wavelength matrix-assisted laser desorption/ionization of proteins with delayed-extraction time-of-flight mass spectrometry. J Am Soc Mass Spectrom 1998 9 879-884. 

Juhasz, P., Roskey, M.T., Smirnov, I.P., Haff L.A., Vestal, M.L., and Martin, S.A. (1995) Applications of delayed extraction matrix- assisted laser desorption ionization time- of-flight mass... 

S.A. (1997) On the initial velocity of ions generated by matrix-assisted laser desorption ionization and its effect on the calibration of delayed extraction time-of-flight mass spectra. J. Am. Soc. Mass Spectrom., 8, 209-217. 

Menzel, C., Berkenkamp, S., and Hillenkamp, F. (1999) Infrared matrix-assisted laser desorption/ ionization mass spectrometry with a transversely excited atmospheric pressure carbon dioxide laser at 10.6 pm wavelength with static and delayed ion extraction. Rapid Commun. Mass Spectrom., 13, 25-32. 

G. (1998) Time-delayed extraction matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry of polyacrylonitrile and other synthetic polymers with the matrix 4-hydroxybenzylidene malononitrile. Rapid Common. Mass Spectrom., 12, 1344-1350. 

To compensate for the energy spread, the first stage of the two-stage acceleration field can be activated shortly after ion production or ejection from the sample. This event typically occurs in the nanosecond to low microsecond range. The method is known as time-lag focusing or delayed extraction technique. In TOF-MS equipped with matrix-assisted laser desorption/ionization (MALDI) ion source, delayed extraction may improve the mass resolving power by a factor of two- to fivefold [9, 10]. Mass resolving power defines the sharpness of spectral features, which is explained in Chapter 5. 

Juhasz, P. Vestal, M.L. Martin, S.A On the Initial Velocity of Ions Generated hy Matrix-Assisted Laser Desorption Ionization and Its Effect on the Calibration of Delayed Extraction Time-of-Hight Mass Spectra. J. Am. Soc. Mass Spectrom. 1997,8,209-217. 

Bahr, U., StahlZeng, J., Gleitsmann, E. and Karas, M., Delayed extraction time-of-flightMALDI mass spectrometry of proteins above 25,000 Da. J. Mass Spectrom., 32, 1111-1116 (1997). Brown, R.S. and Lennon, J.J., Mass resolution improvement by incorporation of pulsed ion extraction in a matrix-assisted laser-desorption ionization linear time-of-flight mass-spectrometer. AwaZ. Chem., 67, 1998-2003 (1995). 

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