Matrix-assisted laser desorption ionization automation

Jarman, K. H. Cebula, S. T. Saenz, A. J. Peterson, C. E. Valentive, N. B. Kingsley, M. T. Wahl, K. L. An algorithm for automated bacterial identification using matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem. 2000, 72, 1217-1223. 

Kang, M.-J., Tholey, A., Heinzle, E. Application of automated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the measurement of enzyme activities. Rapid Commun. Mass Spectrom. 2001, 15, 1327-1333. 

C. Ericson, Q. T. Phung, D. M. Horn, E. C. Peters, J. R. Fitchett, S. B. Ficarro, A. R. Salomon, L. M. Brill, and A. Brock, An automated noncontact deposition interface for liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry, Anal. Chem., 75 (2003) 2309-2315. 

Stevenson, T. I. Loo, J. A. Greis, K. D. 1998. Coupling capillary high-performance liquid chromatography to matrix-assisted laser desorption/ionization mass spectrometry and N-terminal sequencing of peptides via automated microblotting onto membrane substrates. Anal. Biochem., 262,99-109. 

Stoeckli, M. Farmer, T. B. Caprioli, R. M. 1999. Automated mass spectrometry imaging with a matrix-assisted laser desorption ionization time-of-flight instrument. J. Am. Soc. Mass Spectrom., 10, 67-71. 

An automated noncontact deposition interface for liquid chromatography matrix-assisted laser desorption/ ionization mass spectrometry. 

S.B. Salomon, A.R. Brill, L.M. Brock, A. An Automated Noncontact Deposition Interface for Liquid Chromatography Matrix-Assisted Laser Desorption/ionization Mass Spectrometry, Anal. Chem. 75(10), 2309-2315 (2003). 

Also the use of an EWOD system for the automated sample preparation of peptides and proteins for matrix-assisted laser desorption-ionization mass spectrometry (MALDI-MS) was reported. In that work, standard MALDI-MS reagents, analytes, concentrations, and recipes have been demonstrated to be compatible with the EWOD technology, and mass spectra comparable to those collected by conventional methods were obtained [271]. Also a PCR assay has been realized on the platform by temperature cycling of a droplet at rest [272]. Additional informations about the EWOD platform can be found in a comprehensive review [273]. 

Kabel M A, Schols H A, Voragen A G J (2001). Mass determination of oligosaccharides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry following HPLC, assisted by on-line desalting and automated sample handling. Carboh. Polym. 44 161-165. 

While advances in automation have increased the throughput of polymer synthesis, macromolecular characterization remains a significant bottleneck in high-throughput approaches. Typical characterization methods such as matrix-assisted laser desorption/ionization (MALDI) spectrometry and nuclear magnetic resonance (NMR) spectroscopy are not yet amenable to high-throughput analysis, while Fourier transform infrared (FTIR) spectroscopy is now available... 

Onnerfjord P, Ekstrom S, Bergquist J, Nilsson J, Laurell T, Marko-Varga G. Homogeneous sample preparation for automated high throughput analysis with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 1999 13 315-322. 

Brock, A., Horn, D.M., Peters, E.C., Shaw, C.M., Ericson, C., Phung, Q.T., and Saloma, A.R. (2003) An automated matrix-assisted laser desorption/ ionization quadrupole Fourier transform ion cyclotron resonance mass spectrometer for bottom-up proteomics. Anal. Chem., 75, 3419-3428. 

Jensen, O.N., Mortensen, P., Vorm, 0., and Mann, M. (1997) Automation of matrix-assisted laser desorption/ ionization mass spectrometry using fuzzy logic feedback control. Anal Chem., 69, 1706-1714. 

Ruh, H., Sandhoff, R., Meyer, B., Gretz, N., and Hopf, C. 2013. Quantitative characterization of tissue globotetraosylceramides in a rat model of polycystic kidney disease by primadrop sample preparation and indirect high-performance thin layer chromatography-matrix-assisted laser desorption/ionization-time-of flight-mass spectrometry with automated data acquisition. Anal. Chem., 85 6233-6240. 

---