Mass spectrometry imaging metabolites

Benabdellah F, Touboul D, Brunelle A, Laprevote O (2009) In situ primary metabolites localization on a rat brain section by chemical mass spectrometry imaging. Anal Chem 81 5557-5560. doi 10.1021/ac9005364... [Pg.416]

Wiseman J, Ifa D, Zhu Y, Kissinger C, Manicke N, Kissinger P, Cooks R (2008) Desorption electrospray ionization mass spectrometry imaging drug and metabolites in tissues. Proc Natl Acad Sci USA 105(47) 18120-18125. doi 10.1073/pnas.0801066105... [Pg.419]

Li F, Hsieh Y, Kang L, Sondey C, Lachowicz J, Korfmacher W (2009) MALDI-tandem mass spectrometry imaging of astemizole and its primary metabolites in rat brain sections. Bioanalysis l(2) 299-307. doi 10.4155/BIO.09.27... [Pg.422]

In a separate study, a protocol for Matrix-assisted laser desorption-ionization (MALDI) imaging mass spectrometry (IMS) has been proposed.18 This IMS technique provides a new approach to visualize spatial distribution of thousands of molecular species, including peptides, proteins, and their metabolites in two- or three-dimensional levels. This approach may also provide a straightforward method of determining the tissue distribution of multiple peptides or proteins in a quantitative manner.18 Chu et al.19 reported a nondestructive molecular extraction method to obtain proteins from a single FFPE or frozen tissue section, without destroying the tissue morphology, such... [Pg.394]

Cornett, D. S., Frappier, S. L., and Caprioli, R. M. (2008). Imaging drugs and metabolites in tissue using Fourier transform mass spectrometry. In Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics. ASMS, Denver, CO. [Pg.66]

Fig. 2 (a) The optical image of a rat brain from a coronal section, (b) Matrix-assisted laser desorp-tion/ionization (MALDI)-mass spectrometry (MS)/MS images of astemizole in the rat brain slice without perfusion and (c) with perfusion cortex, hippocampus, corpus callosum, hypothalamic region, thalamus region, choroid plexus, dorsal third ventricle, and lateral ventricle are indicated by arrows, (d) MALDI-MS/MS images of M-14 metabolite of astemizole in the rat brain slice (Li et al. [152], Reproduced with permission from Future Science Ltd)... [Pg.410]

Cornett D, Frappier S, Caprioli R (2008) MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue. Anal Chem 80 5648-5653. doi 10.1021/ac800617s... [Pg.417]

Burrell M, Earnshaw C, Clench M (2007) Imaging matrix assisted laser desorption ionization mass spectrometry a technique to map plant metabolites within tissue at high spatial resolution. J Exp Bot 58(4) 757-763. doi 10.1093/jxb/erll39... [Pg.418]

Nemes P, Woods A, Vertes A (2010) Simultaneous imaging of small metabolites and lipids in rat brain tissue at atmospheric pressure by laser ablation electrospray ionization mass spectrometry. Anal Chem 82 982-988. doi 10.1021/ac902245p... [Pg.419]

Liu Q, Xiao Y, Pagan-Miranda C, Chiu Y, He L (2009) Metabolite imaging using matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS). J Am Soc Mass Spectrom 20 80-88. doi 10.1016/j.jasms.2008.09.011... [Pg.420]

Drexler D, Garrett T, Cantone J, Diters R, Mitroka J, Conaway M, Adams S, Yost R, Sanders M (2007) Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissue. J Pharmacol Toxicol Methods 55 279-288. doi 10.1016/j. vascn.2006.11.004... [Pg.420]

Atkinson S, Loadman P, Sutton C, Patterson L, Clench M (2007) Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumors by imaging matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom 21 1271-1276. doi 1002/rcm.2952... [Pg.422]

P Michelsen, AA Karlsson. Accurate mass determination of a metabolite of a potential diagnostic imaging drug candidate by high performance liquid chromatography with time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 13 2146—2150, 1999. [Pg.83]

Cellular Metabolites. - A review of methods for the measurement of ml has been produced with 95 references. It examines the quantitative measurement of ml by mass spectrometry and in vivo NMR. The NMR chemical shifts and /-coupling values of 35 metabolites which can be detected by in vivo or in vitro investigations of the mammalian brain have been published. The principles and recent applications of dynamic nuclear polarisation, which combines the sensitivity to oxygen of EPR and the tractability of NMR imaging, have been reviewed with 244 references. A review of studies of intermediary metabolism, including the use of NMR in the analysis of substrate selection under in vivo conditions, has been produced. A review has been produced, with 74 references, on the study of metabolic flux and subcellular transport of metabolites using NMR. " ... [Pg.391]

Last but not the least, matrix-assisted laser-desorption ionization (MALDI) imaging mass spectrometry (IMS) caught a lot of attentions in the drug metabolism area. Drug distribution and individual metabolite distributions within... [Pg.249]

Trim, P.J. Avery, J.L. McEwen, A. Snel, M.F. Claude, E. Marshall, P.S. West, A. Princivalle, A.P. Clench, M. MALDI-ion mobility separation-MS imaging of Vinblastine and its metabolites in rat tissue. Proc. 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, June 1-5, 2008, MP 130. [Pg.235]

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