MART proteins

KER, keratin, as detected by a mixture of CAM5.2, MAK-6, and AEl /AE3 EMA, epithelial membrane antigen VIM, vimentin DES, desmin MSA, muscle-specific actin SMA, smooth muscle (alpha isoform) actin CALD, h-caldesmon S-IOOP, S-100 protein TY, tyrosinase Ml, MART-1 (melan-A) OGN, osteocalcin EPS, epithelioid sarcoma EPSS, epithelioid synovial sarcoma EAS, epithelioid angiosarcoma EMPNST, epithelioid malignant peripheral nerve sheath tumor CCS, clear cell sarcoma SEFS, sclerosing epithelioid fibrosarcoma ... 

S-100 protein reactivity generally should be considered as melanomas. This is especially true if concomitant positivity is obtained for HMB-45, HMB-50, tyrosinase, or MART-1, because the latter four markers are only rarely associated with nerve sheath tumors. Despite the production of collagen type IV by nerve sheath cells, the immunohistochemical detection of this marker has limited value in the diagnosis of schwannian neoplasms because cells with smooth muscle, endothelial, and myo-fibroblastic differentiation may also synthesize it. 

FIGURE 7.9 Global cytoplasmic immunoreactivity is seen in this primary superficial spreading melanoma, for MART-1/melan-A protein. 

Chen YT, Stockert E, Jungbluth A, et al. Serological analysis of Melan-A (MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas. Proc Natl Acad Sci USA. 1996 93 5916-5919. 

Kawakami Y, Battles JK, Kobayashi T, et al. Production of recombinant MART-1 proteins and specific anti-MART-1 polyclonal and monoclonal antibodies use in the characterization of the human melanoma antigen MART-1. J Immunol Methods. 1997 202 13-25. 

DeVries TJ, Trancikova D, Ruiter DJ, et al. High expression of immunotherapy candidate proteins gplOO, MART-1, tyrosinase, and TRP-1 in uveal melanoma. Br J Cancer. 1998 78 1156-1161. 

Furthermore, they may assume the guise of a small-cell neoplasm, closely resembling SCNC. Immunohisto-chemical characteristics of small-cell melanomas include uniform labeling for S-100 protein, tyrosinase, MART-... 

Millar EK, Beretov J, Mart P, et al. Malignant phyllodes tumours of the breast display increased stromal p53 protein expression. Histopathology. 1999 34 491-496. 

Ceron, J. J., P. D. EckersaU, and S. Mart ez-Subiela. 2005. Acute phase proteins in dogs and cats Current knowledge and future perspectives. Veterinary Clinical Pathology 34 85-89. 

D. Juretic, N. Trinajstic, and B. LuCic, Protein secondary structure conformations and associated hydrophobicity scales,/. Mart. Chem. 74,35-34(1993). 

Melan A Malan A is a protein encoded by the MART-1 gene. Melan A is expressed in melanin producing cells and considered as a specific melanocyte differentiation and melanoma marker. 

Thornton, P.D., Mart, R.J., Webb, S.J. Ulijn, R.V. 2008, Enzyme-responsive hydrogel particles for the controlled release of proteins designing peptide actuators to match payload . Soft Matter, vol. 4, no. 4, pp. 821-827. 

Hermsdorff, H.H., Barbosa, K.B., Volp, A.C., Puchau, B., Bressan, J., Zulet, M.A., Mart A. Advanced oxidation protein products (AOPPs) in juvenile overweight and obesity prior to and following weigntioxidant capacity, and central adiposity indicators. Eur. J. Prev. Cardiol. 2012 41(12) 943 9. 

Immxmodrug carrier QbClO CYT004-MelQbC10 vaccine containing Melan-A/MART-1 protein Melanoma P-n (CB)... 

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