Lobophytum crassum

Matthie. G.F. Konig, G.M. Wright, A.D. (1998) Three new diterpenes from the marine soft coral Lobophytum crassum. J. Nat. Prod., 61, 237-40. 

A n.m.r. study of the 14-membered ring diterpenoids has been published. The Coelenterata have been the source of a number of macrocyclic diterpenoids. The cembranolides of marine origin have been reviewed. The structure (96) of a new sinulariolide, from Sinularia notanda, is also reported in this review. The soft coral Lobophytum crassum afforded (97)/ which is an isomer of lobophytolide, and crassolide (98). The keto-epoxide (99) and the 13-membered ring-contraction product (100) were obtained from another Lobophytum species. 

Tursch B, Braekman JC, Daloze D, Dedeurwaerder H, Karlsson R (1978) Chemical studies of marine invertebrates. XXXI(l). Crassolide, a highly oxygenated diterpene from the soft coral lobophytum crassum. (Coeltmterata, Octocorallia, Alcyonacea). Bull Soc Chim Beiges 87 75... 

Vicinal /hh couplings have been extensively applied by many authors in structural and stereochemical studies of natural products. Thus, they have been used by Guo and co-workers to establish the structure of four new ot-methylene-y-lactone-bearing cembrane diterpenoids from Lobophytum crassum. Further examples include two new sesquiterpenes isolated from Cyperus rotundus L. by Xu et three new eudesmanohdes, ten sesquiterpenes extracted from Inula helenium, by Ma et two lactone... 

Kashman, Y., S. Carmely, and A. Groweiss Further Cembranoid Derivatives from the Red Sea Soft Corals Alcyonium flaccidum and Lobophytum crassum. J. Org. Chem. 46, 3592(1981). 

Duh, C.-Y, Wang, S.-K., Huang, B.T., and Dai, C.-F. (2000a) Cytotoxic cembrenolides diterpenes from the Formosan soft coral Lobophytum crassum.J. Nat. Prod., 63,884-885. 

Vanisree, M. and Subbaraju, G.V. (2002) Alcyonacean metabolites VIII-antibacterial metabolites from Lobophytum crassum of the Indian Ocean. Asian J. Chem., 14, 957—960. 

Lobophytum crassum with inhibitory effects on nitric oxide production. Chem. Pharm. Bull., 58,1203-1209. 

Yin, S.-W., Shi, Y-P Li, X.-M., and Wang, B.-G. (2006) A new cembranoid diterpene and other related metabolites from the South-China-Sea soft coral Lobophytum crassum. Hdv. Chim. Acta, 89, 567-572. 

Zhang, W., Krohn, X, Ding, J., Miao, Z.-H., Zhou, X-H., Chen, S.-H., Pesticelli, G., Salvadori, P Kiutan, T., and Guo, Y.-W (2008) Structural and stereochemical studies of a a-methylene-y-lactone-bearing cembrane diterpenoids from a South China sea soft coral Lobophytum crassum. J. Nat. Prod., 71,961-966. 

Sinularia leptoclados (A) Cladiella humesi (A) Lobophytum crassum (A) Nephthea sp. (A)... 

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