Marine macrolide bioactive

Higa, T., and Tanaka, J. (1997). Bioactive marine macrolides. In Studies in Natural Products Chemistry (A. Rahman, Ed.), Vol. 19, pp. 549-626. Elsevier Science, Amsterdam. 

A series of review articles on the synthesis of biofunctional molecules have appeared and several of these describe extensive use of phosphorus-based olefination reactions, for example, in the synthesis of vitamin D, tetramic acids, polyene macrolide antibiotics and bioactive marine macrolides. ... 

Abstract Recent progress (2002-2005) of total syntheses of bioactive marine macrolides, lasonolide A, zampanolide, dactylolide, and leucascandrolide A, was described. The stereoselective construction of tetrahydropyrans, which are important units involved in these natural products, is also summarized. 

Pietra and co-workers first reported the isolation, stmctural elucidation, and bio-logicl activity of a powerfully bioactive marine macrolide, leucascandrolide A, in 1996 [70]. Leucascandrolide A (2.60) was isolated from a from a the calcareous sponge of a new genus, Leucascandra caveolata collected from the east coast of New Caledonia in 1989 [70]. Leucascandrolide B was also isolated from the same sponge, however, it has shown to have few structural similarities and significantly... 

Norcross RD, Paterson I. Total synthesis of bioactive marine macrolides. Chem. Rev. 1995 95 2041-2114. 

Norcross, R. D. Paterson, I. Total Synthesis of Bioactive Marine Macrolides. Chem. Rev. 1995, 95, 2041-2114. 

Kobayashi J, Kubota T. Bioactive macrolides and polyketides from marine dinoflagellates of the genus Amphidinium. J. Nat. Prod. 2007 70 451-460. 

ABSTRACT Marine invertebrates such as ascidians, sponges and others are a prolific source of bioactive secondary metabolites. We have isolated a variety of marine natural products from the Okinawan marine invertebrates by using the sea urchin egg assay. Our recent work, the isolation, structure determination and activities of chlorinated macrolides, sesterterpenic acids, a bromotyrosine derivative, acetogenin derived endoperoxides, diterpene alkaloids, sesquiterpene quinones and spiro-sesquiterpenes, is presented in this article. The syntheses of these metabolites are also described. 

Bioactivity-guided fractionation of organic extracts of Cladosporium herbarum, isolated from the marine sponge Callyspongia aerizusa, yielded two new macrolide metabolites, pandangolide 3 172 and 4 173, and a anti-microbial active (against Bacillus subtilis and Staphylococcus aureus) new fliran carboxylic acids, acetyl Sumiki s acid 174/ ... 

In the screening of marine streptomycete isolates for bioactive components, a new macrolide antibiotic designated as chalcomycin B 258... 

Kobayashi J, Tsuda M. Amphidinolides, bioactive macrolides from s3fmbiotic marine dinoflagellates. Nat. Prod Rep. 2004 21 77-93. 

Fusetani N, Shinoda K, Matsunaga S. Bioactive marine metabolites. 48. Cinachyrolide A a potent cytotoxic macrolide possessing two spiro ketals from marine sponge Cinachyrasp. J. Am. Chem. Soc. 1993 115 3981. 

Kobayashi, J., Shimbo, K, Kubota, T, and Tsuda, M. (2003) Bioactive macrolides and polyketides from marine dinoflagellates. Pure Appl. Chem., 75, 337-342. 

Matsunaga, S., Liu, P., Celatka, C.A., Paneck, J.S., and Fusetani, N. (1999b) Relative and absolute stereochemistry of mycalobdes, bioactive macrolides from the marine sponge Mycale magdlanica. J. Am. Chem. Soc., 121, 5605—5606. 

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