Bioactive marine metabolites

Hashimoto, Y. Marine Toxins and Other Bioactive Marine Metabolites Japan Scientific Societies Press Tokyo, 1979 pp. 1-151. 

Hashimoto, Y. In "Marine Toxins and Other Bioactive Marine Metabolites" Japan Scientific Societies Tokoyo, 1979 ... 

This reaction has been used as the key step in the synthesis of some important bioactive marine metabolites by treatment of readily available 2-vinyltetrahydrofurans with dichloroketene (equation 199)713. 

Most of the highly bioactive marine metabolites are also highly toxic, which is very serious. If enough materials are available, parent compounds could be modified to reduce their toxicity or to improve their therapeutic efficacy. However, such attempts have not been accomplished because of limited amounts of materials and their highly complex structures, except for readily synthesized substances such as didemnins and dolastatins. 

BIOACTIVE MARINE METABOLITES FROM OKINAWAN WATERS... 

Two other pyrrolopyrimidine nucleoside antibiotics, mycalisines A and B (56,57), have been isolated from the sponge Mycale sp. (173). These bioactive marine metabolites inhibit cell division of starfish eggs. 

Fusetani, N., Matsunaga, S., and Konosu, S. (1981) Bioactive marine metabolites... 

Pursuit of novel bioactive marine metabolites 06Y471. 

Fusetani, N., Asano, Matsunaga, S., Hashimoto, K., (1986). Bioactive marine metabolites. XV. Isolation of aplysinopsin from the scleractinian coral Tubastrea aurea as an inhibitor of development of fertilized sea urchin eggs. Comp. Biochem. Phys. B 85B, 845-846. 

Fusetani, N., Kakao, Y., Matsimaga, S., (1991). Bioactive marine metabolites. 39. Nazumamide A, a thrombin -inhibitory tetrapeptide, from a marine sponge, Theonella sp. Tetrahedron Lett. 32, lOTi-lDlA. 

Fusetani, N., Matsunaga, S., Matsumoto, H., Takebayashi, Y., (1990). Bioactive marine metabolites. 33. Cyclotheonamides, potent thrombin inhibitors, from a marine sponge Theonella sp. J. Am. Chem. Soc. 112, 7053-7054. 

Matsunaga, S., Fusetani, N., Konosu, S., (1985). Bioactive marine metabolites, IV. Isolation and the amino acid composition of discodermin A, an antimicrobial peptide, from the marine sponge Discodermia kiiensis. J. Nat. Prod. 48, 236-241. 

Kita M, Sakai E, Uemura D (2006) Pursuit of novel bioactive marine metabolites. J Synth Org Chem Jpn 64 471... 

Hashimoto Y (1979) Marine organisms which cause food poisoning. In Marine toxins and other bioactive marine metabolites, Japan Scientific Societies Press, Tokyo, Japan, p 91-105. 

Fusetani, N., S. Matsunaga, and S. Konosu Bioactive Marine Metabolites. II. Halistanol sulfate, an Antimicrobial Novel Steroid Sulfate from the Marine Sponge Halichondria CF. moorei Bergquist. Tetrahedron Lett. 22, 1985 (1981). 

Fusetani, N., Y. Kato, S. Matsunaga, and K. Hashimoto Bioactive Marine Metabolites. V. Two New Furanosesterterpenes, Inhibitors of Cell Division of the Fertilized Starfish Eggs, from the Marine Sponge Cacospongia scalaris. Tetrahedron Lett. 25, 4941 (1984). 

Bioactive Marine Metabolites VI. Structure Elucidation of Discodermin A,... 

Fusetani, N., Shinoda, K., and Matsunaga, S. (1993b) Bioactive marine metabolites. 48. Cinachyrohde A a potent cytotoxic macrolide possessing two spiro ketals from marine sponge Cinachyra sp. /. Am. Chem. Soc., 115, 3977-3981. 

Hamada, T, Sugawara, T, Matsrmaga, S., and Fusetani, N. (1994a) Bioactive marine metabolites. 55. Polytheonamides, imprecedented highly cytotoxic polypeptides from the marine sponge Theondla swinhoei 1. Isolation and component aminoacids. Tetrahedron Lett., 35, 719-720. 

Matsunaga, S., Fusetam, N., and Konosu, S. (1985a) Bioactive marine metabolites VII. Structures of discodermins B, C, and D antimicrobial peptides from the marine sponge Discodermia kiiensis. Tetrahedron Lett., 26,855-856. 

Fusetani, N Shiragaki, T Matsunaga. S., and Hashimoto, K. (1987c) Bioactive marine metabolites XX. Petrosynol and petrosynone, antimicrobial Cjo polyacetylenes from the marine sponge Petrosia sp. determination of the absolute corrfiguration. Tetrahedron Lett., 28,4313-4314. 

Fusetani, N., Sugawara, T., Matsunaga, S., and Hirota, H. (1991c) Bioactive marine metabolites. Part 35. Cytotoxic metabolites of the marine sponge Mycale adhaerens Lambe. J. Org. Chem., 56, 4971-4974. 

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