Manganese superoxide dismutase MnSOD

Hohmeier, H.E., Thigpen, A., Tran, V. V., Davis, R. andNewgard, C.B. (1998) Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1 beta-induced cytotoxicity and reduces nitric oxide production. J. Clin. Invest., 101, 1811-1820. 

Manganese superoxide dismutase (MnSOD) is a redox-active manganese enzyme that employs a mononuclear manganese ion at its active site. Discovered in 1970 (52), this enzyme catalyzes the dismuta-tion of superoxide (H02), to dioxygen and hydrogen peroxide, as shown in Scheme 2. Superoxide is the radical, one-electron-reduced... 

Studies on some cell lines have shown that in tumor models such as mouse epidermal 1B6 cells and MCF-7, ROS were observed to stimulate cell growth in monolayers. In other cell lines, ROS can also be involved in the pathogenesis of cancer. By promoting cell proliferation in the transformed cancer cell lines MCF-7, HeLa, and Jurkat cells, reduced antioxidant levels were implicated in malignant transformation. Overexpression of manganese superoxide dismutase (MnSOD), a normal cellular antioxidant, enzyme was reported to revert transformation or tumor-promotion response in these and other transformed cell tines, such as human melanoma (UACC-903) cells, human breast cancer (MCF-7) cells, and mouse epidermal JB6 cells. ... 

Epperly MW, Defilippi S, Sikora C et al. (2000a) Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation. Gene Ther 7 1011-1018... 

Epperly MW, Epstein CJ, Travis EL et al. (2000b) Decreased pulmonary radiation resistance of manganese superoxide dismutase (MnSOD)-deficient mice is corrected by human manganese superoxide dismutase-Plasmid/Liposome (SOD2-PL) intratracheal gene therapy. Radiat Res 154 365 374... 

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