Malignant results

Risk factors for the development of AML include exposure to environmental toxins, Hispanic ethnicity, and genetics.6 Of greater concern is the increased prevalence of AML as a secondary malignancy, resulting from chemotherapy and radiation treatment for other cancers. Alkylating agents, such as ifosfamide and cyclophosphamide, and topoisomerase inhibitors, such as etoposide, are linked to an increased risk of myelodysplastic syndrome (MDS) and AML.8... 

Kummar, S., Kinder, R., Gutierrez, M., Rubinstein, L., Parchment, R., Phillips, L., Low, J., Murgo, A., Tomaszewski, J., and Doroshow, J. (2007). Inhibition of poly (ADP-ribose) polymerase (PARP) by ABT-888 in patients with advanced malignancies Results of a phase 0 trial. In American Society of Clinical Oncology Meeting. Chicago, IL. 

Sterman, D. H., Treat, J., Litzky, L. A., Amin, K. M., Coonrod, L., Molnar-Kimber, K., Recio, A., Knox, L., Wilson, J. M., Albelda, S. M. and Kaiser, L. R. (1998). Adenovirus-mediated herpes simplex virus thymidine kinase/ ganciclovir gene therapy in patients with localized malignancy Results of a phase I clinical trial in malignant mesothelioma. Hum. Gene Ther. 9, 1083-1092. 

Duval, M., Suciu, S., Ferster, A., Rialland, X., Nelken, B., Lutz, P., Benoit, Y., Robert, A., Manel, A. M., Vilmer, E., Otten, J. and Philippe, N. (2002). Comparison of Escherichia coli-asparaginase with Erwin V/-asparaginasc in the treatment of childhood lymphoid malignancies results of a randomized European Organization for Research and Treatment of Cancer-Children s Leukemia Group phase 3 trial. Blood 99, 2734-2739. 

The childhood tumors, such as Wilms s tumor and retinoblastoma, are a special group. They occur in infancy or childhood and apparently have a uniform incidence among all racial and geographic groups. Some cases are clearly inherited others are sporadic. One hypothesis is that the malignancy results from two mutations. If both mutations are somatic, that accounts for the sporadic cases. In retinoblastoma, mutations frequently affect only one eye. In the hereditary cases, one mutant gene is inherited from a parent and the second occurs somatically usually both eyes are affected. If this simple hypothesis is correct, the mutation component is the fraction of hereditary cases, estimated to be about one-third of all cases.21 ... 

Curley, S.A., Izzo, R, Delrio, R, Ellis, L.M., Granchi, X, Vallone, R, Fiore, F., Pignata, S., Daniele, B., Cremon, F. Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies - Results in 123 patients. Ann. Surg. 1999 230 1-8... 

Sadeghi B, Arvieux C, Glehen O, et al. Peritoneal carcinomatosis from non-gynecologic malignancies results of the EVOCAPE 1 multicentric prospective study. Cancer. 2000 88 358-363. 

Tumor progression in gliomas is associated with an increase in the grade of malignancy, resulting in a... 

Buscarini L, Buscarini E (2001) Therapy of HCC radiofrequency ablation. Hepatogastroenterology 48 15-19 Buscarini L, Buscarini E, Di Stasi M etal. (2001) Percutaneous radiofrequency ablation of small hepatocellular carcinoma long-term results. Eur Radiol 11 914-921 Curley SA, Izzo F, Delrio P et al. (1999) Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies results in 123 patients. Ann Surg 230 1-8 Curley SA, Izzo F, Ellis LM et al. (2000) Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg 232 381-391... 

Curley SA, Izzo F, Delrio P et al (1999) Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies results in 123 patients. Ann Surg 230 1-8... 

Pawlik TM, Izzo F, Cohen DS, et al (2003) Combined resection and radiofrequency ablation for advanced hepatic malignancies results in 172 patients. Ann Surg Oncol 10 1059-1069... 

Patt YZ, McBride CM, Ames FC, et al (1987) Adjuvant perioperative hepatic arterial mitomycin C and floxuridine combined with surgical resection of metastatic colorectal cancer in the liver. Cancer 59 867-873 Pawlik TM, Izzo F, Cohen DS, et al (2003) Combined resection and radiofrequency ablation for advanced hepatic malignancies results in 172 patients. Ann Surg Oncol. 10 1059-1069... 

Sterman DH, Treat J, Litzky LA, AminK, Molnar-Kimber K, Wilson J, Albelda SM, Kaiser LR. Adenovirus-mediated herpes simplex vims thymidine kinase gene delivery in patients with localized malignancy results of a phase 1 clinical trial in malignant mesothelioma. Hum Gene Ther 1998 9 1083-1092. 

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