Malignancy clinical applications

Kobata A (1987) Malignant transformational changes of the sugar chain and their clinical applications. In Greene MI, Hamaoca T (Eds) Development and recognition of the transformed cells. Plenum New York, p 385... 

This volume continues our objective of expanding the intellectual horizon of clinical chemistry. Included are chapters on Clinical Applications of Cytokine Assays Diagnosis and Treatment of Acute Pancreatitis Mitochondrial Mutations and Mitochondrial Diseases Pathobiochemistry of Nephrotic Syndrome Total Antioxidant Capacity Autoantibodies to dsDNA, Ro/SSA, and LaSSB in Systemic Lupus Erythematosis and Lymphoid Malignancies and Immunosuppressive Analysis. The meld of analytical, anatomical, subcellular, and molecular sciences represented by these subjects will continue to evolve and expand. Clinical chemistry is a vibrant and vital profession. Future volumes, their editors, and their contributors will undoubtedly be an important part of the practice and science of clinical chemistry. 

Shah AC, Benos D, Gillespie GY, Markert JM (2003), Oncolytic viruses clinical applications as vectors for the treatment of malignant gliomas, J. Neurooncol. 65 203-226. 

Caudana, R., Morasna, G., Pirovano, G.P. Focal malignant hepatic lesions MR imaging enhanced with gadolinium benzyloxy-propion-ictetra-acetate (BOPTA) - preliminary results of phase II clinical application. Radiology 1996 199 513-520... 

The development of PDT and especially PDD for clinical applications is just beginning. Currently only 4 photosensitisers are in clinical oncological use. Despite its still experimental status, the available data indicate that PDT bears the potential as a second line treatment for malignant brain tumors and might be the future first line treatment for recurrent brain tumors. 

Advances in tumor biology, recombinant antibody technology, and radio synthetic chemistry have led to a flurry of activity in the development and clinical application of endoradiotherapeutic agents. However, it is important to bear in mind that radionuclide therapy is actually not a new concept, having been used in patients for more than 60 years. A number of textbooks provide excellent chronicles of early efforts in radionuclide therapy (Spencer 1978 Harbert 1987 Spencer et al. 1987). A notable example is sodium [ ijiodide, which has been utilized for the treatment of hyperthyroidism and thyroid carcinomas and remains the most widely utilized targeted radiotherapeutic in current clinical use. Radiocolloids such as those labeled with either Au or have been used for more than 50 years for the treatment of diseases such as malignant pleural effusions and intraperitoneal tumors. 

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