Tumor biology

Patient and tumor biology also affect how cancer therapy is dosed. Patients with a uridine diphosphate-glucuronosyltransferease 1A1 enzyme deficiency can have... 

Emmett V. Schmidt Laboratory of Tumor Biology, MGH Cancer Center, Massachusetts General Hospital, Charelestown, MA 02129, USA... 

Vascular and Tumor Biology Research Center The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute Technion-Israel Institute of Technology Efron St., POB 9649 Haifa, 31096 Israel... 

Department of Clinical Research, Tumor Biology Center, Freiburg, Germany... 

Microbiology and Tumor Biology Center, Karolinska Institutet Box 280, S-171 77 Stockholm, Sweden E-mail nico.dantuma mtc.ki.se maria.masucci mtc.ki.se... 

Microbiology and Tumor Biology Center, Korolinsko Institutet, Stockholm, Sweden... 

These finding require further investigation to determine the relationship between tumor biology and defects of Fas-mediated apoptosis. Indeed, Fas gene mutations were first reported in Ipr and mice (A2, L5, W1) and were recently reported in... 

Like these ATL studies, other interesting studies (B2, N4) have been instructive about the relationship between other Fas isoforms and tumor biology. These studies showed that the presence of alternative splicing isoforms, such as sFas with deleted... 

Fig. 6. Survival curves of ATL groups classified according to mFas (A) and sFas status (B). Prognosis could not be predicted by mFas status (a v. b), but could be predicted by sFas status (c v. d), suggesting that the sFas isoform plays a more important role in tumor biology than mFas in some ATL cases.

If Fas gene mutations are significant in tumor biology, mutations may be clustered in the most important region of the gene. Accordingly, the hot spot of the mutations in cancers and the relationship between the mutation domain and the functional impairment are discussed in this section. 

---