Maleic acid Methylamine

A solution of N-(2-aminobenzvl)-1-phenyl-2-metKylaminoethanol-1 was prepared by the reaction of a-bromo-acetophenone and (2-nitrobenzyl)methylamine, followed by hydrogenation of the nitro group by means of nickei on diatomaceous earth at room temperature and reduction of the CO group by means of sodium borohydride. The intermediate thus produced was dissolved in 100 ml of methylene chloride and introduced dropwise into 125 ml of sulfuric acid at 10° to 15°C. After a short standing, the reaction mixture was poured onto ice and rendered alkaline by means of a sodium hydroxide solution. Dy extraction with ether, there was obtained 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-amino-iso-quinoline. The base is reacted with maleic acid to give the maleate melting point of the maleate 199° to 201°C (from ethanol). 

A recent addition to this field is the polymer-supported di(2-pyridyl)-methylamine-palladium dichloride complex covalently attached to a styrene-alt-maleic acid anhydride copolymer. Turnover numbers as high as 105 were reported and a couple of microwave-heated Suzuki-Miyaura reactions could be performed in neat water [134], 2-Pyridinealdoxime-based Pd(II)-... 

Didecyl methylamine Maleic acid/acrylic acid copolymer Maleic acid/olefin copolymer, sodium salt Nonyi nonoxynol-150 PPG-7-buteth-10... 

Other preparative routes iaclude hydrogenation of succinonitdle in the presence of methylamine and hydrogenation of solutions of maleic or succinic acid and methylamine (82,83). Properties are Hsted in Table 3. l-Meth5i-2-pyrrohdinone is completely miscible with water, lower alcohols, lower ketones, ether, ethyl acetate, chloroform, and benzene. It is moderately soluble in aUphatic hydrocarbons and dissolves many organic and inorganic compounds. 

Using maleic aldehyde, acetonedicarboxylic acid and methylamine hydrochloride in aqueous solution, in presence of sodium acetate, Iheobrazhenskii, Rubtsov, Dankova and Pavlov have prepared troperume. 

The cycloaddition of maleic anhydride to 3-methyl-4-methylaminopyrazol-5-selenone (582) in dioxane gave 4,5,6-tetrahydroselenopyrano[2,3-c]pyrazole-5,6-dicarboxylic acid anhydride (583) (75%). Treatment of this adduct (583) with base promoted the elimination of methylamine giving the diacid (584) (Scheme 73) <79KGS527>. 

HYDROXYETHYL)METHYLAMINE (109-83-1) Combustible liquid (flash point 165°F/74°C oc). A strong organic base. Violent reaction with acids, strong oxidizers. Incompatible with organic anhydrides, acrylates, alcohols, aldehydes, alkylene oxides, substituted allyls, cellulose nitrate, cresols, caprolactam solution, epichlorohydrin, ethylene dichloride, glycols, isocyanates, ketones, maleic anhydride, nitrates, phenols, vinyl acetate. Increases the explosive sensitivity of nitromethane. Attacks aluminum, copper, zinc, and their alloys. 

Wang and co-workers [6] used a Py-GC technique for the qualitative analysis of fumaric acid and itaconic acid as low-level monomers polymerised with other major monomers in emulsion styrene maleic anhydride co-polymers. In order for fumaric acid and itaconic acid to be detected through pyrolysis, the acids are derivatised with primary amines such as methylamine and ethylamine to form a cyclic imide. The detection of derivatised fumaric acid and itaconic acid was accomplished by atomic emission detection. The structures of the derivatisation-pyrolysis products were elucidated by MS. 

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