Maleate Syrup

Add items 3 and 4 while mixing to dissolve at high speed. 

Mix for 5 minutes. Add item 2 while mixing at slow speed. Temperature 95° to 98°C. 

Mix for 1 hour at high speed. Cool down to 30°C while mixing at slow speed. 

Transfer the solution to the manufacturing vessel above while mixing at high speed. Mix for 2 minutes. 

0 g of cold item 8 (25° to 30°C) in a separate container and dissolve item 1 by using stirrer. Mix for 10 minutes and transfer to the manufacturing vessel above. 

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Tussafed Syrup—dextromethorphan HBr, carbinoxam-ine maleate, pseudoephedrine HC1 Tussend Tablets—hydrocodone bitartrate, chlorpheniramine, pseudoephedrine HC1 Vanex HD Liquid—hydrocodone bitartrate, chloqihen-iramine, phenylephrine HC1... 

Claritin D—pseudoephedrine HC1, loratadine Deconamine Syrup—pseudoephedrine HQ, chloqiheni-ramine maleate... 

AH-Chew Tablets—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate D.A. Chewable Tablets—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate Dallergy Syrup or Tablets—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate Dehistine Syrup—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate Extendryl Syrup—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate Pannaz Tablets or Syrup—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate Rescon-MX Tablets—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate... 

Formulation(s) syrup 0.5 mg (as dimaleate) tabl. 1 mg (azatadine maleate)... 

A cough syrup contains 5 mg of brompheniramine maleate in each 5-mL dose. How many milligrams of brompheniramine maleate would be contained in a 120-mL container of the syrup ... 

The obtained results indicated that this procedure could be applied for the determination of ibuprofen, pseudoephedrine hydrochloride, chlorpheniramine maleate and nipagen in syrup preparations. 

Pharmaceutical grade ibuprofen, pseudoephedrine HCl, chlorpheniramine maleate, nipagen and syrup preparation were kindly supplied by Berko tlag Sanayi A. , Istanbul. 0.03 M H PO and KH PO solutions were prepared with analytical grade chemicals and milliQ water. HPLC grade acetoiutrile was used. 

The vast majority of salt forms are developed to enhance the aqueous solubihty of drug substances. In some cases, a salt may be preferred with reduced solubihty for use in suspension formulations where solubihty as low as possible is optimum to prevent Ostwald ripening, for taste masking or to prepare a sustained release product. Chlorpromazine is marketed as a tablet and syrup using the hydrochloride salt but the insoluble embonate salt is used in suspension formulations to extend the duration of achon and minimize taste problems. Occasionahy the selection of a salt with only modest aqueous solubihty may be more suitable for use in tablet products prepared by wet granulation. For example, prochlorperazine maleate is used in Stemehl tablets rather than the highly soluble mesylate salt. 

The residual syrup containing the two /-(+)-propanol amides of d,Z-lysergic acid is treated with methanol and excess maleic acid to convert the two amides into their maleate salts. The mixture of amide maleates is precipitated from the methanol solution by the addition of ethyl ether, and the precipitated mixture is filtered off and dried in air. Source Garbrecht 1956... 

Cough-cold preparations Paracetamol, dextromethorphan hydrobromide and chlorpheniramine maleate in antitussive syrups Partition Permaphase ODS Methanol/buffer solution... 

Carbinoxamine compound syrup (Pennex) containing 60 mg pseudoephedrine HCl, 4 mg carbinoxamine maleate, and 15 mg dextromethorphan HBr in 0.2% alcohol is indicated for relief of cough and upper respiratory systems including nasal congestion associated usually with allergy or common cold. Carbinoxamine possesses Hj antihistaminic activity with mild anticholinergic-sedative properties. Carbinoxamine, which is metabolized completely, has a serum half-life of 10 to 12 hours. 

Application of 2 fractional factorial design allowed the optimization of the gradient HPLC procedure for the determination of ibuprofen, pseudoephedrine HCl, chlorpheniramine maleate and nipagen in syrup preparation. The optimum conditions for this determination were found to be 3 of pH, 1.5 mL/min of flow rate, 85%, 55% and 40% of buffer compositions of steps of gradient profile. 

One of the active ingredients in Triaminic cold syrup is hsted as chlorpheniramine maleate. What does the word maleate indicate about the structure of this active ingredient ... 

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