Syrups pseudoephedrine

Tussafed Syrup—dextromethorphan HBr, carbinoxam-ine maleate, pseudoephedrine HC1 Tussend Tablets—hydrocodone bitartrate, chlorpheniramine, pseudoephedrine HC1 Vanex HD Liquid—hydrocodone bitartrate, chloqihen-iramine, phenylephrine HC1... 

Claritin D—pseudoephedrine HC1, loratadine Deconamine Syrup—pseudoephedrine HQ, chloqiheni-ramine maleate... 

Pseudoephedrine hydrochloride can be considered a stable compound in bulk and in formulations. After 4-weeks under fluorescent lights (2400 ft. candles) and ultraviolet light (190 pw/cm2) no discoloration or chemical degradation was observed. The bulk drug was stable for at least 6 months at 37°C and 3 months at 50°C. Tablet and syrup formulations stored at 15-30°C for 5 years showed no appreciable degradation. 13... 

An ultraviolet spectrophotometric method based on the absorbance of a periodate oxidation product of pseudoephedrine hydrochloride will be the official method of analysis in the USP XX.19,20 A portion of tablets or syrup in water is placed in a separatory funnel. Sodium bicarbonate and sodium metaperiodate are added. After standing for 15 minutes, 1 N HC1 is added. The solution is extracted with hexane. The hexane extract is filtered and its absorbance determined at 242 nm in 1 cm cells. The amount of the oxidation product of pseudoephedrine hydrochloride is determined by comparison of the sample absorbance against the absorbance of a Pseudoephedrine Hydrochloride Reference Standard treated in the same manner. 

Pseudoephedrine hydrochloride in syrup formulations has been analyzed by colorimetry. Pseudoephedrine forms a stable blue-colored chelate with cupric sulfate at pH 12.5. The complex has a maximum absorbance at 500 nm. The complex is extracted from an aqueous layer with 1-pentanol. Interfering substances such as glycerine and sugars normally found in syrup formulations, which form complexes with cupric sulfate, are not extracted into 1-pentanol.21... 

The obtained results indicated that this procedure could be applied for the determination of ibuprofen, pseudoephedrine hydrochloride, chlorpheniramine maleate and nipagen in syrup preparations. 

Pharmaceutical grade ibuprofen, pseudoephedrine HCl, chlorpheniramine maleate, nipagen and syrup preparation were kindly supplied by Berko tlag Sanayi A. , Istanbul. 0.03 M H PO and KH PO solutions were prepared with analytical grade chemicals and milliQ water. HPLC grade acetoiutrile was used. 

Syrup with pseudoephedrine HPLC Dilute with 0.01. V acid Silica... 

Also available with pseudoephedrine 120-240 mg Supplied 30-, 60-, 180-mg tablets 60-mg capsule Also available with pseudoephedrine 120-240 mg Supplied 5,10 mg syrup OTC... 

Carbinoxamine compound syrup (Pennex) containing 60 mg pseudoephedrine HCl, 4 mg carbinoxamine maleate, and 15 mg dextromethorphan HBr in 0.2% alcohol is indicated for relief of cough and upper respiratory systems including nasal congestion associated usually with allergy or common cold. Carbinoxamine possesses Hj antihistaminic activity with mild anticholinergic-sedative properties. Carbinoxamine, which is metabolized completely, has a serum half-life of 10 to 12 hours. 

Application of 2 fractional factorial design allowed the optimization of the gradient HPLC procedure for the determination of ibuprofen, pseudoephedrine HCl, chlorpheniramine maleate and nipagen in syrup preparation. The optimum conditions for this determination were found to be 3 of pH, 1.5 mL/min of flow rate, 85%, 55% and 40% of buffer compositions of steps of gradient profile. 

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