Digoxin tablets

HF, and digitalization is begun. The primary healtii care provider prescribes digoxin (Lanoxin) 0.75 mg PO as die initial dose Available are digoxin tablets of 0.5 and 0.25 mg. The nurse administers. ... 

Fig. 6 Dissolution of digoxin tablets containing different fillers (in simulated gastric fluid at 37°C). (From Ref. 45.)...

If a prescription requires a stat dose of 0.375 mg of Lanoxin (gen) and the pharmacist has digoxin tablets of strength, 0.25 mg, how many digoxin tablets should the patient take ... 

Insufficient analytical sensitivity for low-dose drugs, especially at higher media volumes (as illustrated in the USP monograph on digoxin tablets). 

Digoxin injection is frequently used to achieve rapid digitalization, with conversion to digoxin tablets or capsules for maintenance therapy. If patients are switched from IV to oral digoxin formulations, make allowances for differences in bioavailability when calculating maintenance dosages (see Pharmacology). 

Tablets-A single initial dose of 500 to 750 meg (0.5 to 0.75 mg) of digoxin tablets usually produces a detectable effect in 0.5 to 2 hours that becomes maximal in 2 to 6 hours. Additional doses of 125 to 375 meg (0.125 to 0.375 mg) may be given cautiously at 6- to 8-hour intervals until clinical evidence of an adequate effect is noted. The usual amount of digoxin tablets that a 70 kg patient requires to achieve 8 to 12 mcg/kg peak body stores is 750 to 1250...

Usual Digoxin Tablet Daily Maintenance Dose Requirements (meg) for Estimated... 

Drug/Food Interactions When digoxin tablets are taken after meals, the rate of absorption is slowed but total amount absorbed is usually unchanged. However, when taken with meals high in bran fiber, the amount absorbed may be reduced. 

If you have done some clinical work you may have noticed that digoxin tablets come in two dose sizes - 0.25 mg (usually white), and 0.0625 mg (or 62.5 microgram - often blue in colour). One brand name is Lanoxin PG . Did you know that the PG stands for paediatric-geriatric which recognizes the immature kidneys of the infant and the failing kidneys of the elderly and the need to give smaller doses at both ends of life to avoid digoxin toxicity ... 

Determination of ethinyloestradiol in tablets Determination of the dissolution rate of digoxin tablets... 

Digoxin capsules (Lanoxicaps) have greater bioavailability than digoxin tablets. 

Jedlicka A, Grafnetterova T, Miller V. 2003. HPLC method with UV detection for evaluation of digoxin tablet dissolution in acidic medium after solid-phase extraction. J. Pharm. Biomed. Anal. 33 109 115. 

The development of low-dose formulations is certainly not new to the pharmaceutical industry one obvious example is the long-term clinical use of digoxin tablets. However, with the introduction of new technologies to identify molecular... 

Manufacturers are expected to produce a formulation with an unvarying bioavailability so that the same amount of drug is released with the same speed from whatever manufactured batch or brand the patient may be taking. Substantial differences in bioavailabUity of digoxin tablets from one manufacturer occurred when only the technique and machinery for making the tablets were changed also tablets containing the same amount... 

Pharmacopoeias generally do not require a dissolution profile to be determined but do specify that a certain amount of drug must dissolve (or not dissolve in the case of enteric-coated products) within a specified time. Should a single-time specification be stated, the test may be concluded in a shorter time if the requirement for a minimum amount dissolved is met. If two or more times are specified, then the samples should be withdrawn with a tolerance of 2% of the stated time. For Digoxin Tablets BP, when there is more than one tablet per test, all six replicate runs should release at least 75% of the stated amount within 60 minutes. 

Polyoxyl 40 hydrogenated castor oil (Cremophor RH 40) and polyoxyl 60 hydrogenated castor oil are largely unaffected by the salts that cause hardness in water. Cremophor RH 40 was found to prolong the dissolution time of digoxin tablets. ... 

De Rick, A., Chakrabarti, S., Belpaire, F. Bogaert, M. (1979) Bioavailability of three brands of digoxin tablets in dogs. Journal of Veterinary Pharmacology and Therapeutics, 2, 27-29. 

Fluorimetry is approximately fOO times more sensitive than ultraviolet spectroscopy and is ideal for the analysis of very small amounts of potent drugs. Examples are the steroids digoxin in Digoxin Tablets BP and the contraceptive agent ethinylestradiol, which is present at levels of only 30 pg per tablet. 

A 39-year-old man with mitral stenosis ingested 90 digoxin tablets (0.25 mg each) in a suicide attempt approximately 2 hours before admission. Upon admission, the blood pressure was 110/70 mm Hg and the pulse was 40-60/min and irregular. The rest of the examination was normal. 

Six months after starting digoxin therapy, the patient attempts suicide by swallowing 75 digoxin tablets (0.25 mg each). He is discovered by his wife and brought to the emergency... 

Two single-dose studies have found 42% and 62% reductions in the bioavailability of digoxin caused by kaolin-pectin. Another study found an interaction with digoxin tablets but not with digoxin capsules. ... 

A study in 11 patients taking slowly dissolving digoxin tablets Oriori) found that metoclopramide 10 mg three times a day for 10 days reduced the serum digoxin levels by 36%, from 0.72 to 0.46 nanograms/mL. The digoxin concentrations rose to their former levels when the metoclopramide was withdrawn. 

Fraser EJ, Leach RH, Poston JW, Bold AM, Culank LS, Lipede AB. Dissolution-rates and bioavailability of digoxin tablets. Lancet (1913) i, 1393. 

It was suggested that Crenwphor increases digoxin plasma levels by inhibiting intestinal P-glycoprotein, or that the Crenwphor prolongs the dissolution of digoxin tablets resulting in delayed absorption from the intestines. ... 

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