Magnetic microsphere

Chen et al. (163) targeted magnetic microspheres containing 5-fluorouracil to the esophagus by application of an external magnet. 

EE Hassan, RC Parish, JM Gallo. Optimized formulation of magnetic microspheres containing the anticancer agent, oxantrazole. Pharm Res 9 390-397,... 

K. J. Widder and A. E. Senyei, Magnetic microsphere A vehicle for selective targeting of organs, in Methods of Drug Delivery (G. M. Ihler, ed.), Pergamon Press, New York, 1986, p. 39. 

Steinkamp [91] for the Luminex microspheres. Recently, Mayr et al. stained magnetic microspheres with luminescent ruthenium(II) metal ligand complexes [92] which were encoded by time resolved imaging in the microsecond domain. 

McNaughton BH, Kinnunen P, Smith RG, Pei SN, Torres-Isea R, Kopelman R, Clarke R (2009) Compact sensor for measuring nonlinear rotational dynamics of driven magnetic microspheres with biomedical applications. J Magn Magn Mater 321 1648-1652... 

Widder K, Flouret G, Senyei A (1979) Magnetic microspheres synthesis of a novel parenteral drug carrier. J Pharm Sci 68 79-82. 

Several methods for separating cells have been devised. These include electrophoresisd or use of magnetic microspheres. b Micromanipulation can sometimes be used to select single cells for analysis. The most impressive technique is flow cytometry,ef which is used daily on human blood samples in clinical laboratories. A suspension of cells is passed at a high rate of flow through a narrow capillary of 0.2 mM diameter. The sample stream, which is surrounded by a larger "sheath" stream, has a... 

Kemshead, J. T, Heath, F., Gibson, F. M., Katz, F, Richmond, F, Treleaven, J., andUgelstad, J. (1986) Magnetic microspheres and monoclonal antibodies for the depletion of neuroblastoma cells from bone marrow experiences, improvements and observations, Br. J. Cancer 54, 771—778. 

Guadernack, G, Leivestad, T., Ugelstad, J, and Thorsby, E (1986) Isolation of pure functionally active CD8+ T cells positive selection with monoclonal antibodies directly conjugated to monosized magnetic microspheres. J Immunol Methods 90, 179-187... 

Leivestad, T., Guadernack, G., Ugelstad, J., Vartdal, F, and Thomsby, E (1987) Isolation of pure and functionally active T4 and T8 cells by positive selection with antibody-coated monosize magnetic microspheres Transplantation Proc 19, 265-267. 

Detection of multiple species on a single chip is possible by fixing a probe molecule (often DNA) to a polymer layer covering the sensor, as shown in Fig. 3. The analyte DNA is a single strand complementary to the probe DNA and is labeled (often with biotin). Magnetic microspheres functionalized with streptavidin (which attaches to biotin) are then introduced the microspheres bind to the biotin, which is present only on the successfully trapped DNA. 

The signal measured by sensor can be used to quantify the amount of analyte present. The response to the sensor is determined by the in-plane component of the stray fields induced by the magnetized microspheres. Concentrations as low as 3.2 pg/ml have been detected [98], The introduction of tunneling magnetoresistance (TMR) sensing elements and smaller magnetic markers will increase the sensitivity of the method. 

The synthesis of stimuli-responsive polymer gel microspheres have been receiving growing attention [67-69,73]. Polymer microspheres that combine both temperature- and pH-responsive volume phase transitions have been elaborated, as reported by many authors [2,5-7,65,66]. Owing to their relatively rapid and easy magnetic separation, thermosensitive polymer magnetic microspheres could be widely used in biomedical and bioengineering, such... 

The method of cell separation using a magnetic field has been implemented as a binary separation between cells that have and have not boimd magnetic microspheres on the basis of a cell receptor (a specific type of smface Ugand), as shown in Fig. 1. 

In order to prepare core-shell magnetic microspheres for use as an MRI contrast agent, double hydrophilic block copolymers of PEO-Wock-PGA have also been investigated by another research group [106]. 

However, the use of water-soluble monomer in emulsion polymerization is more complicated. A potential example is the synthesis of thermally sensitive magnetic microspheres using water-soluble NIPAM, using the combination of emulsion polymerization and then seeded precipitation polymerization [140, 141], Lee et al. [140] conducted the synthesis of magnetic latex by a two-stage process at the first... 

The use of DVB in emulsion polymerization for the preparation of functional magnetic microsphere was described by Zhao et al. [147]. 

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