Macrophage foreign antigens

An APC is a cell that displays a foreign antigen complex with MHC on its cell surface. Its major responsibility is to present these foreign antigens to T cells. T cells can identify this complex using their T-cell receptors (TCRs). There are three main types of APCs dendritic cells, macrophages, and activated B cells. Dendritic cells (DCs) are present in tissues that... 

Class II MHC proteins occur on the surfaces of a few types of specialized cells, including macrophages and B lymphocytes that take up foreign antigens. Like class I MHC proteins, the class II proteins are highly polymorphic, with many variants in the human popula-... 

APC, antigen-presenting cells are bone-marrow-derived cells, macrophages and dendritic cells which process foreign antigens and present them to T cells, OR, adenomatous polyposis coli protein, enoded by the human ape gene. 

Macrophages bridge innate and adaptive immunity. After they have devoured foreign antigens or microbes as part of their role in innate immunity, they assist B cells and T cells in adaptive responses... 

FIGURE 53-2 Cytokine cell interactions. Macrophages, T cells, B cells, and marrow stem cells interact via several cytokines (IL-1, IL-2, IL-3, IL-4, IFN [interferon]-"X GM-CSF, and G-CSF) in response to a bacterial or a foreign antigen challenge. 

In the reticuloendothelial system of animals, various cell populations cooperate to produce the humoral immune response. These cells circulate throughout the body in the blood and lymph systems. They are found in especially high concentrations in the spleen and the lymph nodes. Foreign antigens are initially recognized by scavenger surveillance cells called macrophages. 

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