Lupus erythematous

Hypersensitivity Anaphylactoid purpura, anaphylaxis, angioneurotic edema, myocarditis, pericarditis, polyarthralgia, pulmonary infiltrates with eosinophilia, systemic lupus erythematous exacerbation, urticaria hypersensitivity syndrome (cutaneous reaction, eosinophilia, and one or more of the following Hepatitis, pneumonitis, nephritis, myocarditis, pericarditis, fever, lymphadenopathy). Muscuioskeietai - ArVr ra g a, arthritis, bone discoloration, joint stiffness and swelling, myalgia, polyarthralgia. 

Hematologic abnormalities, including myelosupression, unusual bleeding, drug fever, renal complications, and lupus erythematous-like reaction including fever, arthralgia, and lymphadenopathy rarely occur. 

Jennekens FG, Kater L (2002a). The central nervous system in systemic lupus erythematous. Part 1. Clinical syndromes a literature investigation. Rheumatology (Oxford) 41 605-618... 

D The prolonged administration of procainamide often leads to the development of a positive ANA test result, with or without symptoms of a lupus erythematous-like syndrome. The common symptoms of lupus erythematous-like syndrome are arthralgia, malaise, rash, fever, chills, and arthritis, which may occur more often in slow acetylators because they do not metabolize procainamide as well. If a positive ANA titer develops, assess the benefit/risk ratio related to continued procainamide therapy. 

It has been reported that NZBWF, mice, routinely used as a model of systemic lupus erythematous,25 26 have less affinity for L-tryptophan binding to hepatic nuclei than do other mice strains (Swiss, DBA, SJL, and BALB/c).27 This decreased binding affinity of NZBWFj mice appears to correlate with the decreased effect of L-tryptophan administration on hepatic protein synthesis as compared to Swiss mice.27 Also, hepatic nuclei of NZBWFj mice revealed a significantly decreased binding response of 3H-tryptophan in comparison to those of Swiss mice when nuclei of both groups were affected by Showa Denko L-tryptophan (implicated in eosinophilia-myalgia syndrome) or to its contaminants, l,l -ethylidenebis-(tryptophan) and 3-phenylamino-L-alanine, in contrast to that of control nonimplicated L-tryp-tophan.28... 

Systemic lupus erythematous is an autoimmune disease characterized by a particular spectrum of autoantibodies against many cellular components, including chromatin, ribonucleoprotein, and cell membrane phospholipids. In this disorder, the body makes these antibodies against its own components. snRNPs are one of the targets of these antibodies. In fact, snRNPs were discovered as a result of studies using antibodies obtained from patients with SLE. 

Precautions Moderate use is rarely harmful. A possible allergen. Individuals with Systemic Lupus Erythematous (SLE) must avoid. 

Ziegler V, Pfeil B, Haustein UF (1991) Berufliche Quarzstaubex-position - Progressive Sklerodermie und Lupus erythemat-odes. Z Hautkr Geschlechtskr 66 968-970... 

A 25-year-old Caucasian woman taking hydroxychloroquine for discoid lupus erythematous developed generalized symmetrical depigmentation of the scalp and body hair, or acquired poUosis. Hydroxychloroquine was withdrawn and she grew new hair in her natural color within 3 months. 

Seligmann, M. Mise en Evidence dans le serum de malades atteints de lupus erythemat-eux diss6min6 d une substance determinant une reaction de precipitation avec Tacide desoxyribonucl ique. C. R. Acad. Sci. (Paris) 245, 243-245 (1957). 

Hypersensitivity Anaphylaxis angioedema arthralgia chills drug fever eczematous, erythematous, or maculopapular eruptions lupus-like syndrome associated with pulmonary reactions myalgia pruritus urticaria. 

A 44-year-old woman received interferon alfa 6 MU/ day for relapse of chronic myeloid leukemia 7 years after successful bone marrow transplantation. About 2 years later, interferon alfa was withdrawn because of diffuse erythematous skin lesions with discoid lupus erythematosus on skin biopsy and severe dysphagia with esophagitis and pseudomembranes at endoscopy. Fever, bilateral pulmonary infiltrates, and respiratory distress syndrome subsequently developed, and she required mechanical ventilation. An open lung biopsy showed features of chronic pulmonary graft-versus-host disease. All her symptoms completely resolved with ciclosporin and corticosteroids. An infectious cause was ruled out. 

Other side effects of carbamazepine include hypersensitivity and dermatologic reactions (e.g., pruritic and erythematous rashes, urticaria, photosensitivity reactions, and a systemic lupus... 

Skin pruritic and erythematous rashes, urticaria, toxic epidermal necrolysis, Stevens-Johnson syndrome (see Warnings), photosensitivity reactions, erythema multiforme, aggravation of disseminated lupus erythematosus. 

Skin A 73-year-old woman, with a 30-year history of subacute cutaneous lupus erythematosus presented with an acute flare of her disease, characterised by erythematous, annular and scaly plaques over her trunk and limbs. She had been in remission, and off-treatment for 4 years. One week before, she had been started on therapy with naproxen for arthritis in combination with omeprazole for gastrointestinal protection. Both drugs were discontinued by the patient because of her acute disease flare. Her symptoms resolved after 2 months of oral treatment with prednisolone. Three months later flie patient presented again with another sudden-onset flare of subacute cutaneous lupus erythematosus involving her face, trunk, arms, buttocks and thighs. Two weeks earlier, she had been restarted on naproxen plus omeprazole. On this occasion, the patient was treated with oral prednisolone (40 mg) and hydroxychloroquine (200 mg) twice daily. Mycophenolate mofetil (500 mg twice daily) was introduced 1 week later because of her further deterioration. In the meantime, omeprazole was discontinued. These actions were followed by a dramatic improvement of the subacute cutaneous lupus erythematosus within 5 weeks [53 ]. 

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