Lung carcinoma neuropathy

Paraneoplastic neuropathies often occur in patients with carcinoma. Subacute sensory or sensorimotor axonal polyneuropathy, often with associated limbic encephalitis and cerebellar degeneration, is a common complication of small-cell lung cancer and other carcinomas, occasionally presenting even prior to diagnosis of the underlying neoplasm. Some patients with paraneoplastic neuropathy express anti-Hu antibodies, which recognize epitopes associated with the HuD neuronal RNA binding protein [37,38]. 

Etoposide Etopophos, VePesid Carcinoma of lung, testes Blood disorders (anemia, leukopenia, thrombocytopenia] Gl distress (nausea, vomiting] hypotension, allergic reactions hair loss neurotoxicity (peripheral neuropathies, CNS effects]... 

Two of the most important platinum anticancer drugs are cisplatin (2.13) and carboplatin (2.14). Cisplatin is effective against testicular tumours, ovarian carcinoma and some other types of cancer, but relatively inactive against breast and lung cancers it is also a very toxic compound. Side effects include loss of high-frequency hearing, neuropathy and nausea. Kidney damage may also result, but is minimised... 

Malaise and abdominal pain Peripheral neuropathy and muscular weakness ii. Skin changes (hyperpigmentation and dermatitis) v. Mees lines transverse bands on the fingemniln d. Complications squamous cell carcinoma of jhe-skin and lung 4. Lead poisoning (plumbism)... 

Sensory-nerve conduction responses were unehcita-ble in the lower limbs, while in the upper limbs they showed moderate dysschwannian plus dysneuronal neuropathy (see Vignette 12). BMG showed slight recent denervation and slight reinnervation. Quadriceps muscle biopsy showed slight-moderate recent denervation and moderate reinnervation. CSF protein was elevated at 61 mg/dL (normal up to 45 mg/ dL). Chest X-ray showed hilar lymphadenopathy, and a small lesion in the left lower lung field, biopsy of which disclosed a small-cell carcinoma. 

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