Lung cancer secretion

In addition, several other organs, like the heart, ovaty, amnion, chorion, decidua, testis, epididymis and prostate, have been reported to synthesize OT, suggesting a paracrine role for this hormone in these tissues. Ectopic AVP production by lung cancer cells or other neoplasms has been described in humans, leading to the syndrome of inappropriate antidiuretic hormone secretion. 

Paraneoplastic syndromes are clinical syndromes owing to nonmetastatic systemic effects of cancer. Tumors make and secrete biologically active products that can stimulate or inhibit hormone production, autoimmunity, immune complex production, or immune suppression. Lung cancer, particularly small cell lung cancer, is associated with a high rate of paraneoplastic... 

Paraneoplastic syndromes commonly associated with lung cancers include cachexia, hypercalcemia, syndrome of inappropriate antidiuretic hormone secretion, and Cushing s syndrome. 

Cytotoxic—inhibits growth of carcinoma of the urinary bladder, breasts, esophagus, thorax, and lungs. Increases secretion of cytokins, mainly IL-1 and TNF-a factor Protective factor against cancer Stimulates development of breast cancer Being incorporated into cellular membranes, fats modulate the activity of macrophages. They disturb proliferation of lymphocytes and depress activity of cytotoxic cells They disturb the response dependent on both B and T cells... 

Pulmonary gene therapy is attractive for the treatmment of chronic bronchitis, cystic fibrosis, a-1 antitrypsin deficiency, familial emphysema, asthma, pulmonary infections, surfactant deficiency, pulmonary hypertension, lung cancer, and malignant mesothelioma. The pulmonary endothelium may act as a bioreactor for the production and secretion of therapeutic proteins, such as clotting factors and erythropoietin into the blood circulation. There is a potential benefit for acquired lung diseases, as well as cancers, to be controlled and possibly treated by expression of cytokines, surfactant, antioxidant enzymes, or mucoproteins within lung cells. 

Aii, acute iymphocytic ieukemia CHF, congestive heart faiiure iHD, FHodgkin s disease KS, Kaposi s sarcoma Mi, myocardial infarction NHL, non-Hodgkin s lymphoma NSAiD, nonsteroidal anti-inflammatory drug NSCLC, non-small-cell lung cancer PVC, polyvinyl chloride SIADH, syndrome of inappropriate secretion of antidiuretic hormone SCLC, small cell lung cancer. 

CCL21 promoted fll-integrin expression and MMP-2/MMP-9 secretion as well as TPC-1 cell proliferation [31]. CCL21 also induced ot4[31 integrin-dependent adhesion of human nonsmall cell lung cancer cell line to VCAM-1 [55],... 

Some non-endocrine tumours secrete hormones, e.g. lung cancers may secrete ACTH. 

Hyperparathyroidism is caused by malignancies of the parathyroid glands or ectopic PTH hormone secretion from lung cancer, hyperthyroidism, or prolonged immobility during which calcium is lost from bone. 

Bombesin and gastrin-releasing peptides have been shown to sensitize C-fiber neurons to subsequent activation by capsaicin and ATP. In addition, these peptides enhance the pulmonary chemoreflex induced by C-fiber stimulants. The relevance of these observations may be heightened in small-cell lung cancers, as the cancer cells are known to secrete various peptides, including bombesin-like peptides (Gu and Lee 2005). 

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