Lung cancer fluid

At typical indoor concentrations, COj is not thought to be a direct cause of adverse health effects however, COj is an easily-measured surrogate for other occupant-generated pollutants. Eye, nose, and throat irritation headaches lung cancer may contribute to heart disease buildup of fluid in the middle ear increased severity and frequency of asthma episodes decreased lung function. ETS is also a source of odor and irritation complaints. 

Larger particles (several micrometers in size) are deposited in the ciliated portion and are cleared from the respiratory system by muco-ciliary action into the gastronomical tract, but may produce systemic toxic effects by absorption in body fluids. Finer particles reach the lower non-ciliated portion of the lungs, are cleared very slowly, and are responsible for diseases such as pneumoconiosis and lung cancer. Metallic lead (Pb), tellurium ( ), selenium (Se), and platinum (Pt) are known to cause both systemic and respiratory toxicity in laboratory animals and several cases of acute and chronic poisoning among metal workers have also been documented. 

Docetaxel Inhibits mitosis Breast cancer, non-small cell lung cancer, prostate cancer, gastric cancer, head and neck cancer, ovarian cancer, bladder cancer Hypersensitivity Neurotoxicity, fluid retention, myelosuppression with neutropenia... 

S.A. Ahrendt, J.T. Chow, L.H. Xu, et al. (1999). Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer. J. Natl. Cancer Inst., 91, 332-339. 

A 59-year-old woman with a 60 pack-year smoking history was diagnosed with lung cancer 2 months ago. She now enters the hospital in coma. Her serum calcium is 16 mg/dL. Which of the following (given with IV fluids) would be most useful to reduce serum calcium in this patient rapidly ... 

Beinert, T. et al.. Further evidence for oxidant-induced vascular endothelial growth factor up-regulation in the bronchoalveolar lavage fluid of lung cancer patients undergoing radiochemotherapy, J. Cancer Res. Clin. Oncol, 126 (6), 352-356, 2000. 

Intramacrophagic iron was 0.33 0.21 pgxl0 cells in healthy non-smoking subjects without occupational exposure (Corhay et al. 1992). Intramacrophagic iron was increased in smokers, iron-steelworkers, and in patients with chronic obstructive pulmonary disease or lung cancer even in the absence of pulmonary haemorrhage. About 80 % of the whole bronchoalveolar lavage fluid iron content was in the cells. 

More efficient dmg delivery to tumor, especially of macromolecular dmgs, may be possible by enhancing the EPR effect with the use of various vascular permeability mediators or potentiators. Suppression of the EPR effect by the use of appropriate inhibitors or antidotes, such as the bradykinin antagonist HOE 140 and protease inhibitors or NOS inhibitors, may also be possible. Thus, one may be able to suppress or retard tumor growth and tumor metastasis. Also, by suppressing vascular permeability with antidotes such as the bradykinin antagonist HOE 140, pleural fluid in lung cancer and ascitic fluid in abdominal carcinomatosis may be controlled and the clinical course of cancer patients may be improved. 

H. P. Wang, H. C. Wang and Y. J. Huang, Microscopic FTIR studies of lung cancer cells in pleural fluid, Sci. Total Environ., 1997, 204, 283-287. 

Docetaxel, another taxane, binds to tubulin to promote microtubule assembly. The pharmacokinetics of docetaxel are best described by a three-compartment model, with an a half-life of 0.08 hours, a 3 half-life of 1.6 to 1.8 hours, and a terminal half-life of 65 to 73 hours.14 Docetaxel has activity in the treatment of breast, non-small cell lung, prostate, bladder, esophageal, stomach, ovary, and head and neck cancers. Dexamethasone, 8 mg twice daily for 3 days starting the day before treatment, is used to prevent the fluid retention syndrome associated with docetaxel and possible hypersensitivity reactions. The fluid... 

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