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Lubricants, ophthalmic

PEG-2 hydrogenated tallowamine PEG-20 hydrogenated tallowamine lubricant, ointments PEG-40 stearate lubricant, ophthalmic Polyvinyl alcohol lubricant, paints... [Pg.5445]

The lubricating properties of tears are an important feature in normal blinking. Kalachandra and Shah measured the coefficient of friction of ophthalmic solutions (artificial tears) on polymer surfaces and found no correlation with viscosity, surface tension or contact angle [58]. The coefficient of friction appears to depend on the structure of the polymer surfaces and decreases with increasing load and sliding speed. [Pg.447]

Although usually considered to be inactive ingredients in ophthalmic formulations added because they impart viscosity, many of these polymers function as ocular lubricants. They are marketed as the active ingredients in OTC ocular lubricants used to provide relief from dry eye conditions. The regulatory requirements for these OTC products are found in the FDA Code of Federal Regulations (21CFR349.12), and their formulations are presented in the Twelfth Edition of the APhA Handbook of Nonprescription Drugs. [Pg.459]

An erodible insert developed as a potential ocular drug-delivery system is marketed as a prescription drug for the lubricant properties of the polymer base. Lacrisert is a sterile ophthalmic insert used in the treatment of moderate to severe dry eye syndrome and is usually recommended for patients unable to obtain symptomatic relief with artificial tear solutions. The insert is composed of 5 mg of hydroxypropylcellulose in a rod-shaped form about 1.27 mm diameter by about 3.5 mm long. No preservative is used, since it is essentially anhydrous. The quite rigid cellulose rod is placed in the lower conjunctival sac and first imbibes water from the tears and after several hours forms a... [Pg.465]

Topically administered ophthalmic preparations can affect visual acuity. Examples are lubricating gels and ointments for dry eye, antimicrobial ointments for ocular infections, and gel-forming solutions for glaucoma. Although acuity is only slightly reduced and is only temporary, this effect can be annoying to patients and may lead to noncompliance. [Pg.9]

Nonmedicated ointments are indicated for moderate to severe dry eye, especially with lagophthalmos, persistent inferior corneal stippling, or severe epithelial compromise. Esters of latty acids with long-chain alcohols, such as petrolatum, mineral oil, lanolin, and lanolin alcohols, serve as lubricants and create a lipid layer, retarding evaporation. Although these preparations (Table 14-2) melt at the temperature of the ocular tissue and disperse with the tear fluid, they appear to be retained longer than other ophthalmic vehicles. Because of their molecular... [Pg.272]

Ophthalmic Optically clear Sterile Mucomimetic Lubricating Demulcent Non-irritating or non-sensitizing Water soluble or miscible... [Pg.1882]

Hydroxyethyl cellulose is a nonionic, water-soluble polymer widely used in pharmaceutical formulations. It is primarily used as a thickening agent in ophthalmic and topical formulations, although it is also used as a binder and film-coating agent for tablets. It is present in lubricant preparations for dry eye, contact lens care, and dry mouth. ... [Pg.330]

Therapeutically, mineral oil has been used as a laxative, see Section 14. It is indigestible and thus has limited absorption. Mineral oil is used in ophthalmic formulations for its lubricant properties. It is also used in cosmetics and some food products. ... [Pg.471]

Light mineral oil is used in applications similar to those of mineral oil. It is used primarily as an excipient in topical pharmaceutical formulations where its emollient properties are exploited in ointment bases see Table I. It is also used in ophthalmic formulations. Light mineral oil is additionally used in oil-in-water and polyethlylene glycol/gylcerol emulsions as a solvent and lubricant in capsules and tablets as a solvent and penetration enhancer in transdermal preparations and as the oily medium used in the microencapsulation of many drugs. ... [Pg.474]

Use Tablet binding and coating agent, detoxicant and demulcent lubricant in ophthalmic preparations, film-forming agent in medical aerosols. [Pg.998]

The current management of dry eyes usually includes instilling artificial tears and ophthalmic lubricants, hi general, tear substitutes are hypotonic or isotonic solutions... [Pg.308]

See other pages where Lubricants, ophthalmic is mentioned: [Pg.410]    [Pg.3259]    [Pg.410]    [Pg.3259]    [Pg.420]    [Pg.459]    [Pg.462]    [Pg.9]    [Pg.147]    [Pg.1351]    [Pg.31]    [Pg.45]    [Pg.275]    [Pg.498]    [Pg.508]    [Pg.509]    [Pg.526]    [Pg.1883]    [Pg.1886]    [Pg.2213]    [Pg.592]    [Pg.671]    [Pg.1892]    [Pg.96]    [Pg.103]    [Pg.159]    [Pg.163]    [Pg.476]    [Pg.769]    [Pg.1208]    [Pg.504]    [Pg.507]    [Pg.1114]    [Pg.65]    [Pg.13]    [Pg.92]    [Pg.98]   
See also in sourсe #XX -- [ Pg.1114 ]



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Ophthalmics

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