Loss of growth control

As so many physiological compounds regulating cell growth and metabolism appear to interact with gangliosides as components of cellular receptors, it has been suggested that the loss of growth control in certain transformed cells may partially be based on the altered gaug-lioside composition observed in neoplastic cells.541... 

Most head and neck cancers affecting the mouth, nasal cavities, larynx and pharynx, are squamous ceU carcinomas (SCCHN). Recently, it has been shown that increased expression of epidermal growth factor (EGF) receptor occurs early in squamous ceU carcinogenesis, and is critical for the loss of growth control. Stimulation of the... 

Cancer. Cancer is a cellular malignancy characterized by loss of normal controls resulting in unregulated growth, lack of differentiation, and the abihty to invade local tissues and metastasize. Most cancers are potentially curable, if detected at an early enough stage. The ideal antineoplastic agent would destroy cancer cells without adverse effects or toxicities to normal cells. No such dmg exists. 

The origin of a malignant tumor is a random genetic mutation leading to the loss of mitotic control by the cells. Normal cells experience mutations regularly, and they are necessary mechanisms of adaptation that are strictly controlled. Malignant transformation, however, means a loss of control and a chaotic, uncontrolled growth. 

Imatinib is an inhibitor of the protein tyrosine kinase involved with platelet-derived growth factor (Bcr-ABL). A loss of cellular control of this tyrosine kinase has been identified as a key mechanism for malignant cell growth. The ability of imatinib to inhibit Bcr-ABL provides a rationale for its use in the treatment of human cancers such as Philadelphia... 

Mutations Causing Loss of Growth-Inhibiting and Cell-Cycle Controls... 

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