Loratadine

Lithocholic acid, structure of, 1082 Locant, IUPAC naming and, 87 Lone-pair electrons, 9 Loratadine, structure of, 206 Lotaustralin. structure of. 766 Low -density polyethylene, synthesis of, 1210... 

Example loratadine Official name Example loratadine Trade name (brand name)... 

Antihistamines are drags used to counteract the effects of histamine on body organs and structures. Examples of antihistamines include diphenhydramine (Benadryl), loratadine (Claritin), fexofenadine (Allegra), and cetirizine (Zyrtec). A new antihistamine, deslorata-dine (Clarinex), is die active metabolite of loratadine and is intended to eventually replace loratadine (Claritin). Topical corticosteroid nasal sprays such as fluticasone propionate (Flonase) or triamcinolone ace-tonide (Nasacort AQ) are also used for nasal allergy symptoms. See Chapter 56 for more information on die topical corticosteroids. 

Drowsiness and sedation are common adverse reactions seen with the use of many of the antihistamines. Some antihistamines appear to cause more drowsiness and sedation than others. These dm may also have varying degrees of anticholinergic (cholinergic blocking) effects, which may result in dryness of the mouth, nose, and throat and a thickening of bronchial secretions. Several newer preparations (eg, loratadine) cause little, if any, drowsiness and fewer anticholinergic effects than some of the other antihistamines. Hiotosensitivity may occur with the use of the antihistamines. 

There is an increase in anticholinergic effects when antihistamines are administered with the monamine oxidase inhibitors (MAOIs) and additive sedative effects if administered with central nervous system depressants (eg, narcotic analgesics or alcohol). When cimetidine and loratadine are administered together there is a risk for increased loratadine levels. 

If gastric upset occurs, take this drug with food or meals. Loratadine should be taken on an empty stomach, if possible If the gastric upset is not relieved, discuss this with the primary health care provider. 

Claritin D—pseudoephedrine HC1, loratadine Deconamine Syrup—pseudoephedrine HQ, chloqiheni-ramine maleate... 

C1JH19CIN2 100643-71-8) see Loratadine (4S)-6-chloro-3,4-dibydro-2H-tbieno[3 -e]-l,2-tbiazin-4-ol 1,1-dioxide... 

C23H25NO 101846-87-1) see Butenafine A -(l,l-dimethylethyl)-3-methyl-2-pyridinecarboxamide (C11H16N2O 32998-95-1) see Loratadine... 

C2HLi 1111-64-4) see Levonorgestrel lithium ethyl acetate (C4H7Li02 189811-59-4) see lloprost lithium tri-sec-butyiborohydride (C 2H2 BLi 38727-52-7) see Rosiglitazone loratadine... 

C21H23NO 3967-32-6) see Cyproheptadine l-methylpiperidin-4-ylmagnesium chloride (CfiH 2ClMgN 63463-36-5) see Azatadine Cyproheptadine Ketotifen Loratadine Pizotifen... 

CHF3O3S 1493-13-6) see Loratadine Oseltamivir trifluoromethanesulfonic acid 4-[(2-methylpropyl)amino]-... 

Clough GF, Boutsiouki P, Church MK Comparison 57 of the effects of levocetirizine and loratadine on histamine-induced wheal, flare, and itch in human skin. Allergy 2001 56 985-988. 58... 

Grant JA, Riethuisen JM, Moulaert B, DeVos C A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo sup- 59 pression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects. 

Loratadine 10 mg orally daily Second-line agent for allergic rhinitis during second and... 

First-generation antihistamines are effective, but associated sedation and psychomotor impairment limit chronic use. Efficacy and safety of second-generation antihistamines in children have been demonstrated in clinical trials.33 Cetirizine is indicated for children 6 months of age and older, loratadine for children 2 years of age and older, and fexofenadine for children 6 years of age and older.15... 

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