Loratadine/pseudoephedrine sulfate

LORATADINE/PSEUDOEPHEDRINE SULFATE (Claritin-D 12 hour tablets 120 mg pseudoephedrine sulfate and 5 mg loratadine)... 

Loratadine/pseudoephedrine sulfate is an antihistamine/ decongestant. Loratadine competitively antagonizes histamine at the Hj receptor. Pseudoephedrine causes vasoconstriction and subsequent shrinkage of nasal mucous membranes by alpha-adrenergic stimulation, promoting nasal drainage. They are indicated in the relief of seasonal allergic rhinitis. 

Sun, J., Wang, G., Wang, W., Zhao, S., Gu, Y., Zhang, J., Huang, M., Shao, F., Li, H., Zhang, Q., and Xie, H. (2005). Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies. J. Pharm. Biomed. Anal. 39 217-224. 

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