Loratadine Alcohol

There is an increase in anticholinergic effects when antihistamines are administered with the monamine oxidase inhibitors (MAOIs) and additive sedative effects if administered with central nervous system depressants (eg, narcotic analgesics or alcohol). When cimetidine and loratadine are administered together there is a risk for increased loratadine levels. 

Avoid alcohol during loratadine therapy Monitoring Parameters... 

A sensitive, simple, and specific liquid chromatographic method coupled with electrospray ionization-mass spectrometry for the determination of donepezil in plasma was developed, and its pharmacokinetics in healthy, male, Chinese was studied [34]. Using loratadine as the IS, after extraction of the alkalized plasma by isopropyl alcohol-n-hexane (3 97, v/v), solutes are separated on a Cig column with a mobile phase of methanol-acetate buffer (pH 4.0) (80 20, v/v). Detection is performed with a TOF mass spectrometer equipped with an electrospray ionization source operated in the positive-ionization mode. Quantitation of donepezil is accomplished by computing the peak area ratio (donepezil [M + H](+) m/z 380-loratadine [M + H](+) mlz 383) and comparing them with the calibration curve (r = 0.9998). The linear calibration curve is obtained in the concentration range 0.1-15 ng/ml. The limit of quantitation is 0.1 ng/ml. The mean recovery of donepezil from human plasma is 99.4 6.3% (range 93.4-102.6%). The inter- and intra-day RSD is less than 15%. After an oral administration of 5 mg donepezil to 20 healthy Chinese volunteers, the main pharmacokinetic parameters of donepezil are as follow T(max), 3.10 0.55 h tV2j 65.7 12.8 h C(max), 10.1 2.02 ng/ml MRT,... 

In a comparison of cetirizine and loratadine, cetirizine 10 mg had acute sedative effects and impaired driving performance (65), whereas loratadine had no sedating potential furthermore, there was an additive effect of alcohol and cetirizine but not alcohol and loratadine. However, in a study using a driving simulator cetirizine 10 mg did not affect driving ability (66). In other studies cetirizine 20 mg caused significant sedation, while in one study there was a dose-dependent sedative effect with 10 mg and 20 mg but not 5 mg (67). Pooling the available data (SEDA-16, 163) shows that cetirizine is little more sedative than loratadine and terfenadine. 

Loratadine, U5P. Loratadine. 4-(8-chloro-5,6-dihydro-11 //-benzo[5,6I-cyclohepta 1,2-b py ridin-11 -ylidene-1 -carboxylic acid ethyl ester, is a white to off-white powder not soluble in water but very soluble in acetone, alcohols, and chloroform. 

The non-sedating antihistamines seem to cause little or no drowsiness in most patients and the risks if taken alone or with alcohol appear to be minimal or absent. However, the incidence of sedation varies with the non-sedating antihistamine (e.g. sedation appears to be lower with fexofenadine and loratadine than with acrivastine or cetirizine) and with the individual (e.g. women may be more affected than men). Therefore, patients should be advised to be alert to the possibility of drowsiness if they have not taken the drug before. Any drowsiness would be apparent after the first few doses. The patient information leaflets for acrivastine and cetirizine suggest avoidance of alcohol or excessive amounts of alcohol, and caution is advised with levocetirizine. ... 

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