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Lopinavir

The initial search for an inhibitor of the SARS 3CL protease focused on preexisting drugs and compounds, some tested empirically and others selected based on modeling. The HlV-1 PI nelfinavir and lopinavir/ritonavir have been considered, with the latter actually used clinically in SARS CoV-infected subjects. The rhi-novirus inhibitor ruprintrivir and related compounds have also been tested (reviewed in Fear et al. 2007). However, in the absence of any elements of specificity, these preexisting compounds would be expected to have low potency. [Pg.102]

Jacobson IM, Everson GT, Gordon SC, Kauffman R, McNair L, Muir A, McHutchison JG (2007) Interim analysis results from a phase 2 study of telaprevir with peginterferon alfa-2A and ribavirin in treatment-naive subjects with hepatitis C. AASLD 58th Annual Meet, Abstract 177 Johnson M (2006) Response to Atazanavir/ritonavir versus lopinavir/ritonavir equivalent or different efficacy profiles by HUl. AIDS 20 1987... [Pg.105]

Zidovudine Didanosine Stavudine Lamivudine Abacavir Tenofovir Emtricitabine Nevirapine Efavirenz TMC125 Saquinavir Indinavir Lopinavir Fosamprenavir Atazanavir Tipranavir Darunavir Raltegravir Elvitegravir Enluvirtide Maraviroc Vicriviroc Bevirimat... [Pg.335]

Tenofovir + Emtricitabine Zidovudine + Lamivudine Abacavir + Lamivudine Efavirenz or Nevirapine Lopinavir/r or Atazanavir/r or Eosamprenavir/r or Saquinavir/r... [Pg.336]

Lopinavir/ritonavir, and abacavir or stavudine or tenofovir or didanosine, and lamivudine or emtricitabine... [Pg.1259]

Lopinavir + ritonavir LPV 200 mg + 2 tablets or 5 ml Use with caution in patients Take with food (AUC Nausea, vomiting, diarrhea CYP3A4 inhibitor... [Pg.1264]

Women of reproductive potential prescribed efavirenz should be counseled on its potentially teratogenic effects and the importance of birth control. Additionally, nevirapine, nelfinavir, ritonavir, lopinavir/ritonavir, and tipranavir/ritonavir have been shown to decrease the concentrations of estrogens and/or progestins in oral contraceptives, which could lead to failure.2 For patients prescribed these drugs, barrier forms of contraception are preferred to prevent pregnancy. DepoProvera may be... [Pg.1267]

TC, lamivudine ABC, abacavir APV, amprenavir AST, aspartate aminotransferase ALT, alanine aminotransferase ATV, atazanavir CBC, complete blood cell count D/C, discontinue ddl, didano-sine d4T, stavudine EFV, efavirenz FTC, emtricitabine P1BV, hepatitis B virus F1CV, hepatitis C vims HIV, human immunodeficiency virus IDV, indinavir IV, intravenous LFT, liver function tests LPV/r, lopinavir + ritonavir NNRTI, nonnucleoside reverse transcriptase inhibitor NRTI, nucleoside reverse transcriptase inhibitor NVP, nevirapine PI, protease inhibitor PT, prothrombin time T.bili, total bilirubin TDF, tenofovir disoproxiI fumarate TPV, tipranavir ULN, upper limit of normal ZDV, zidovudine. [Pg.1271]

Lopinavir/ritonavir or atazanavir/ritonavir and (zidovudine or fosamprenavir/ritonavir or tenofovir) and (lamivudine or emtricitabine). [Pg.1275]

Protease inhibitors (amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir) Rifampin... [Pg.350]

Azalides azithromycin Azoles fluconazole, itraconazole, ketoconazole, and voriconazole Macrolides erythromycin, clarithromycin Protease inhibitors amprenavir, indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, and saquinavir Quinolones ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin. [Pg.396]

Lopinavir/ritonavir (twice daily) (coformulated) (All) Alternatives Atazanavir (Bll)... [Pg.452]

Fewer head-to-head data with oncedaily fosamprenavir-ritonavir and lopinavir ritonavir, as well as saquinavir (Invirase) + ritonavir... [Pg.452]

Current recommendations for treating HIV infection advocate a minimum of three antiretroviral agents. The typical regimen consists of two NtRTIs and either a ritonavir-boosted PI or NNRTI. The dual NtRTI backbone should include tenofovir plus emtricitabine (coformulated as Truvada) or zidovudine plus lamivudine (coformulated as Combivir). Abacavir plus lamivudine is an alternative. Recommended initial NtRTIs include atazana-vir-ritonavir, lopinavir-ritonavir, or fosamprenavir-ritonavir. Efavirenz is the recommended NNRTI except for women who plan to become pregnant or who do not have adequate contraception. [Pg.454]

In one of these studies, an effort was made to understand the observed dislipidemia and insulin resistance associated with long-term HIV protease inhibitor therapy [25]. Five HIV protease inhibitors (lopinavir, nelfinavir,... [Pg.422]


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Abacavir Lopinavir

Abbott Laboratories lopinavir

Amiodarone Lopinavir

Amprenavir Lopinavir

Antiretroviral drugs, Lopinavir

Atorvastatin Lopinavir

Azithromycin Lopinavir

Buprenorphine Lopinavir

Darunavir Lopinavir

Efavirenz Lopinavir

Fluticasone Lopinavir

Fosamprenavir Lopinavir

Hormonal) Lopinavir

Human immunodeficiency virus lopinavir

Indinavir Lopinavir

Kaletra - Lopinavir

Lamivudine Lopinavir

Lopinavir Alcohol

Lopinavir Carbamazepine

Lopinavir Clarithromycin

Lopinavir Contraceptives, hormonal

Lopinavir Cyclosporine

Lopinavir Ethanol

Lopinavir Foods

Lopinavir Itraconazole

Lopinavir Maraviroc

Lopinavir Methadone

Lopinavir NRTIs

Lopinavir Nelfinavir

Lopinavir Nevirapine

Lopinavir Nucleoside reverse transcriptase inhibitors (

Lopinavir Omeprazole

Lopinavir Phenytoin

Lopinavir Pravastatin

Lopinavir Quinidine

Lopinavir Rifabutin

Lopinavir Rifampicin

Lopinavir Rifampin

Lopinavir Saquinavir

Lopinavir Stavudine

Lopinavir Tacrolimus

Lopinavir Tenofovir

Lopinavir Tipranavir

Lopinavir Warfarin

Lopinavir Zidovudine

Lopinavir dosing

Lopinavir drug interactions

Lopinavir interactions

Lopinavir receptor antagonists

Lopinavir transcriptase inhibitors

Lopinavir with itraconazole

Lopinavir with other protease inhibitors

Lopinavir, synthesis

Lopinavir/ritonavir

Lopinavir/ritonavir , protease

Lopinavir/ritonavir , protease inhibitor

Lopinavir/ritonavir adverse effects

Lopinavir/ritonavir dosage

Lopinavir/ritonavir drug interactions

Protease inhibitors lopinavir

Rifabutin lopinavir + ritonavir

Rifampicin lopinavir + ritonavir

Ritonavir and lopinavir Oral Solution

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