Lopinavir Alcohol

Fosamprenavir PI2 1400 mg bid or 700 mg bid with ritonavir 100 bid or 1400 mg daily with ritonavir 100-200 mg daily. Adjust dose in hepatic insufficiency Separate dosing from antacids by 2 h. Avoid concurrent high-fat meals Diarrhea, nausea, vomiting, hypertriglyceridemia, rash, headache, perioral paresthesias, t liver enzymes See footnote 4 for contraindicated medications. Do not administer with lopinavir/ritonavir or in severe hepatic insufficiency. Also avoid cimetidine, disulfiram, metronidazole, vitamin E, ritonavir oral solution, and alcohol when using the oral solution... 

Kaletra oral solution is available for oral administration as 80 mg lopinavir and 20 mg ritonavir per milliliter with the following inactive ingredients acesulfame potassium, alcohol, artificial cotton candy flavor, citric acid, glycerin, high fructose com symp, Magnasweet-110 flavor, men-... 

Lopinavir/ritonav ir PI/PI 400 mg/100 mg bid With food. Separate dosing with didanosine by 1 hour. Diarrhea, abdominal pain, nausea The oral solution contains alcohol store capsules and solution in refrigerator see footnote 2 for concurrent drug contraindication s. 

DISULFIRAM ANTIVIRALS-PROTEASE INHIBITORS t risk of disulfiram reaction with ritonavir (with or without lopinavir) Ritonavir and lopinavir/ritonavir oral solutions contain 43% alcohol Warn patients. Consider using capsule preparations as an alternative... 

Clinically important, potentially hazardous interactions with alcohol, anticoagulants, antihistamines, betamethasone, brompheniramine, buclizine, buprenorphine, chlorpheniramine, darunavir, dasatinib, delavirdine, dexamethasone, dicumarol, ethanolamine, fesoterodine, fluconazole, flunisolide, fosamprenavir, hydrocortisone, imatinib, influenza vaccines, lacosamide, lapatinib, lopinavir, meperidine, methylprednisolone, midazolam, nilotinib, piracetam, pizotifen, prednisolone, prednisone, rivaroxaban, rufinamide, solifenacin, telithromycin, temsirolimus, teniposide, trabectedin, triamcinolone, warfarin... 

Lopinavir 5-6 h Chronic Diarrhea, nausea, increased cholesterol and triglycerides, and GGT. Solution contains 42.4% alcohol. ... 

Gomes, C. R. B., Moreth, M., Cardinot, D., Kopke, V., et cd. (2011). Synthesis and antimyco-bacterial activity of novel amino alcohols containing central core of the anti-HIV drugs lopinavir and ritonavir. Chem. Biol. Drug Des., 78,1031-1034. 

Synthesis of Lopinavir and Ritonavir Core In 2007, Menche and co-workers published an asymmetric reductive amination methodology for p-hydroxy ketones 132 for synthesizing a range of l,3-sy -ammo alcohols 135.The reaction was optimized using Ti(Oi-Pr)4 for the coordination of the intermediate imino alcohol 133 and polymethylhydrosiloxane (PMHS) as the hydride source. The reaction was believed to proceed via the initial formation of an imino alcohol that would coordinate to the Lewis acid to undergo reduction through a Zimmerman-Traxler-type transition state 134 to furnish the corresponding iy -l,3-amino alcohol (Scheme 39.40). 

---