Lopinavir hormonal

THYROID HORMONES ANTIVIRALS - PROTEASE INHIBITORS 1 efficacy of levothyroxine by ritonavir (with or without lopinavir) and possibly indinavir and nelfinavir Uncertain possibly T metabolism via induction of glucuronosyl transferases Monitor thyroid function closely... 

Although information is limited, the pharmacokinetic interaction between the ethinylestradiol component of combined hormonal contraceptives and nelfinavir or ritonavir appears to be established and is likely to be clinically important. Similar decreases in plasma levels of ethinylestradiol caused by other drugs have resulted in reduced efficacy and reliability of combined oral contraceptives, and one retrospective report suggests that this has occurred with nelfinavir. It seem likely that the reduced contraceptive levels seen with fosamprenavir, lopinavir and tipranavir were due to the concurrent use of ritonavir (as would be common in practice). Similarly, although no interaction was reported with saquinavir, and raised contraceptive steroid levels were reported with amprenavir and atazanavir, in practice these drugs would be given with ritonavir (as a pharmacokinetic enhancer), and so the levels of combined hormonal contraceptives can reasonably be expected to be reduced. The Faculty ofFamily Planning... 

Endocrine The syndrome of inappropriate antidiuretic hormone (SIADH) has been associated with lopinavir in an HIV-infected 13-year-old boy [122 ]. 

Yeong MM, Palasanthiran P, Ziegler JB, Walls T. Syndrome of inappropriate antidiuretic hormone associated with lopinavir therapy. Pediatr Infect Dis J 2010 29(7) 678-9. 

Musculoskeletal Changes in bone mineral density and bone turnover have been studied in 50 patients taking lopinavir -f ritonavir with either zidovudine - - lamivudine or nevirapine [78 ]. Bone mineral density rapidly fell in both the femoral neck and lumbar spine after the start of therapy, and there was greater loss after 24 months in those who took zidovudine -I- lamivudine. Osteocalcin and the urine deoxypyridinolinexreatinine ratio increased to the same extent in both groups. Changes in parathyroid hormone did not explain the greater bone loss with zidovudine + lamivudine. 

---