Indinavir Saquinavir

Nelfinavir Amprenavir Indinavir Saquinavir Amprenavir Indinavir Ritonavir Saquinavir ... 

Amprenavir (Agenerase) is administered twice daily, providing the patient with an advantage over other protease inhibitors that must be taken more frequently (e.g., indinavir, saquinavir). Common side effects of am-... 

Efavirenz inhibits the plasma levels of indinavir, saquinavir and amprenavir and increases the concentrations of ritonavir and nelfinavir. It also lowers the plasma levels of methadone, phenytoin, carbamazepine and phenobarbital. Drugs that stimulate the cytochrome P-450 system will increase its clearance and should not be coadministered. 

In an in vitro study of the effects of the HIV-1 protease inhibitors, ritonavir, indinavir, and saquinavir, which are metabolized by the liver CYP3A4, all three protease inhibitors inhibited methadone demethylation and buprenor-phine dealkylation in rank order of potency ritonavir > indinavir > saquinavir (53). Clinical studies are required to establish the further relevance of these observations. 

INDINAVIR SAQUINAVIR Possibly t efficacy and t adverse effects of both Inhibition of CYP3A4-mediated metabolism Safety of combination not established. The formulation may affect the interaction. Monitor closely... 

Many tissues also express the same drug export pumps that occur in the barrier epithelial tissues (e.g./ MDR/ MRP/ MXR)/ and these may be important in normal tissues/ as well as in drug-resistant cancers. For example/ P-gp may contribute to resistance to pep-tidomimetic HIV protease inhibitors (e.g./ indinavir/ saquinavir/ and nelfinavir) in AIDS patients. These drugs are substrates for P-gp/ and this transporter... 

Protease inhibitors such as indinavir, saquinavir (for HIV chemotherapy)... 

Indinavir, saquinavir and ritonavir can cause marked rises in serum sildenafil levels. A fatal heart attack occurred in a man taking ritonavir and saquinavir when he also took sildenafil Similar marked interactions occur between vardenafil and indinavir or ritonavir, and are predicted to occur between vardenafil and the other protease inhibitors. Ritonavir caused less marked increases in tadalafil levels. 

Combination of nine ARVs indinavir, saquinavir, ritonavir, amprenavir, lopinavir, delavirdine, efavirenz, elfinavir, and its M8 metabolite... 

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