Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Lithium brain levels

In view of bcl-2 s major neuroprotective and neurotrophic roles, a study was undertaken to determine if lithium, administered at therapeutically relevant concentrations, affects neurogenesis in the adult rodent brain. To investigate the effects of chronic lithium on neurogenesis, mice were treated with therapeutic lithium (plasma levels 0.97 0.20 mM), for 4 weeks. After treatment with lithium for 14 days, the mice were administered single doses of BrdU (bromodeoxyuridine, a thymidine analog which is incorporated into the DNA of dividing cells) for 12 consecutive days. Lithium treatment continued throughout the duration of the... [Pg.404]

Lithium inhibits inositol monophosphate and decreases brain levels of inositol. Belmaker s group [see Levine et ah. Chapter 9, in this volume) showed a selective therapeutic effect of inositol in patients with either depression or panic disorder. Because of the possible importance of the second-messenger system of the phosphatidylinositol [PI) cycle in mood regulation, and because of its influence by lithium, it would be of future in-... [Pg.5]

Hong J-S, Tilson HA, Yoshikawa K Effects of lithium and haloperidol administration on the rat brain levels of Substance P. J Pharmacol Exp Ther 224 590-597, 1983 Honig A, Bartlett JR, Bouras N, et al Amino acid levels in depression a preliminary investigation. J Psychiatr Res 22 159-164, 1989 Honjo H, Ogino Y, Natitoh K, et al In vivo effects by estrone sulphate on the central nervous system on senile dementia [Alzheimer s type). Journal of Steroid Biochemistry 34 521-525, 1989... [Pg.661]

Clinical effects of lithium are slow in onset and may not be apparent before a week or two of daily treatment. Lithium is cleared exclusively by the kidney at a rate 20% of that of creatinine. Clearance is influenced by many factors, including renal function, serum sodium concentration, hydration state, pregnancy, and the presence of other drugs. High urinary levels of sodium inhibit renal tubular reabsorption of lithium, thus decreasing its plasma levels. By decreasing blood volume, thiazides may increase lithium plasma levels. Any drug that can cross the blood-brain barrier can cross the placental barrier The answer is (C). [Pg.267]

To date, there have only been a limited number of studies directly examining PKC in bipolar disorders [77], Although undoubtedly an oversimplification, particulate (membrane) PKC is sometimes viewed as the more active form of PKC, and thus an examination of the subcellular partitioning of this enzyme can be used as an index of the degree of activation. Friedman etal. [78] investigated PKC activity and PKC translocation in response to serotonin in platelets obtained from bipolar-disorder patients before and during lithium treatment. They reported that the ratios of platelet-membrane-bound to cytosolic PKC activities were elevated in the manic patients. In addition, serotonin-elicited platelet PKC translocation was found to be enhanced in those patients. With respect to brain tissue, Wang and Friedman [74] measured PKC isozyme levels, activity and translocation in postmortem brain tissue from patients with bipolar disorder, and reported increased PKC activity and translocation in the brains of bipolar patients compared with controls, effects which were accompanied by elevated levels of selected PKC isozymes in cortices of bipolar disorder patients. [Pg.897]

In a study of psychiatric patients after 1 week of lithium treatment, the serum Li+ level was typically 1 mM, whereas in brain and muscle the levels were 0.4 and 0.5 mM, respectively. Within the brain itself, the distribution of Li+ appears to be uneven however no particular region appears to accumulate Li+ to any significant extent [47]. It has been... [Pg.10]

M20. Morrison, J. M., Pritchard, H. D., Braude, M. C., and D Aguanno, W., Plasma and brain lithium levels after lithium carbonate and lithium chloride administration by different routes in rats. Proc. Soc. Exp. Biol. Med. 137, 889-892 (1971). [Pg.103]

Lithium is readily absorbed from the gastrointestinal tract, reaching a peak plasma level in 2 to 4 hours. Distribution occurs throughout the extracellular fluid with no evidence of protein binding. Passage through the blood-brain barrier is limited, so that cerebrospinal fluid levels are 50% of plasma levels at steady state. [Pg.393]

At present, the possible effects of long-term lithium on the absolute levels of Ga and GOj remain unclear— two independent laboratories have not observed any alterations [Hsiao et al. 1993 Li et al. 1991 Masana et al. 1992], whereas another one has reported small but significant decreases in the levels of the Oij, and Oij rat frontal cortex [Colin et al. 1991]. However, long-term lithium administration reduces the mRNA levels of a number of G proteins in rat brain, including a, Oj, and 0 2 (Colin et al. 1991 Li et al. 1991], suggesting that lithium produces complex transcriptional and posttranscriptional effects after long-term administration [see below]. [Pg.128]

Honchar MP, Ackermann KE, Sherman WR Chronically administered lithium alters neither myo-inositol monophosphatase nor phosphoinositide levels in rat brain. J Neurochem 53 590-594, 1989... [Pg.661]

Kofman O, Sherman WR, Katz V, et al Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures. Psychopharmacology 10 229-234, 1993... [Pg.675]

Kramer MS, Cutler NR, Ballenger JC, et al A placebo-controUed trial of L-365,260, a CCKB antagonist, in panic disorder. Biol Psychiatry 37 462-466, 1995 Krauss GL, Fisher RS Cerebellar and thalamic stimulation for epilepsy, in Electrical and Magnetic Stimulation of the Brain and Spinal Cord. Edited by Devinsky O, Beric A. New York, Raven, 1993, pp 231-245 Krell RD, Goldberg AM Effect of acute and chronic administration of lithium on steady-state levels of mouse brain choline and acetylcholine. Biochem Pharmacol 22 3289-3291, 1973... [Pg.677]


See other pages where Lithium brain levels is mentioned: [Pg.5465]    [Pg.132]    [Pg.5464]    [Pg.401]    [Pg.33]    [Pg.436]    [Pg.401]    [Pg.403]    [Pg.405]    [Pg.411]    [Pg.214]    [Pg.344]    [Pg.752]    [Pg.10]    [Pg.345]    [Pg.207]    [Pg.70]    [Pg.309]    [Pg.5]    [Pg.117]    [Pg.119]    [Pg.120]    [Pg.121]    [Pg.123]    [Pg.124]    [Pg.126]    [Pg.127]    [Pg.128]    [Pg.130]    [Pg.131]    [Pg.132]    [Pg.133]    [Pg.134]    [Pg.137]    [Pg.138]    [Pg.140]    [Pg.141]    [Pg.596]    [Pg.728]   
See also in sourсe #XX -- [ Pg.276 ]




SEARCH



Brain levels

© 2024 chempedia.info