Lithium administration

Hypothyroidism Hypothyroidism may occur with long-term lithium administration. Patients may develop enlargement of thyroid gland and increased thyroid-stimulating hormone levels. 

Baptista, T.J., Hernandez, L., Burguera, J.L., Burguera, M., and Hoe-bel, B.G. (1990) Chronic lithium administration enhances serotonin release in the lateral hypothalamus but not in the hippocampus in rats. A microdialysis study. / Neural Transm Gen Sect 82 31-41. 

At present, the possible effects of long-term lithium on the absolute levels of Ga and GOj remain unclear— two independent laboratories have not observed any alterations [Hsiao et al. 1993 Li et al. 1991 Masana et al. 1992], whereas another one has reported small but significant decreases in the levels of the Oij, and Oij rat frontal cortex [Colin et al. 1991]. However, long-term lithium administration reduces the mRNA levels of a number of G proteins in rat brain, including a, Oj, and 0 2 (Colin et al. 1991 Li et al. 1991], suggesting that lithium produces complex transcriptional and posttranscriptional effects after long-term administration [see below]. 

Bher P, de Montigny C Short-term lithium administration enhances serotonergic neurotransmission electrophysiological evidence in the rat CNS. Psychopharmacology 113 69-77, 1985... 

Hesketh JE, Nicolaou NM, Arbuthnott GW, et al The effect of chronic lithium administration on dopamine metabolism in rat striatum. Psychopharmacology 56 163-166, 1978... 

Hoyer D, Clarke DE, Fozard JR, et al VII International Union of Pharmacology classification of receptors for 5-hydroxtryptamine. Pharmacol Rev 46 157-203, 1994 Hsiao JK, Manji HK, Chen GA, et al Lithium administration modulates platelet Gi in humans. Ufe Sci 50 227-233, 1992... 

Lenox RH, Manji HK Lithium, in The American Psychiatric Press Textbook of Psychopharmacology. Edited by Nemeroff C, Schatzberg A. Washington, DC, American Psychiatric Press, 1995, pp 303-349 Lenox RH, Watson DG Lithium and the brain a psychopharmacological strategy to a molecular basis for manic-depressive illness. Chn Chem 40(2 309-314, 1994 Lenox RH, Watson DG, Patel J, et al Chronic lithium administration alters a prominent PKC substrate in rat hippocampus. Brain Res 570 333-340, 1992 Lenzi A, Lazzerini F, Grossi E, et al Use of carbamazepine in acute psychosis a controlled study. J Int Med Res 14 78-84, 1986 Leonard BE Commentary on the mode of action of benzodiazepines. J Psychiatr Res 27 (suppl 1) 193, 1993... 

Bowen RC, Grof P, Grof E. Less frequent lithium administration and lower urine volume. Am J Psychiatry 1991 148 189-192. 

The literature concerning lithium administration to individuals with preexisting brain disease is sparse but indicates the expected increase in brain disability, including in the elderly (Baldessarini, 1978). 

Smith, S., Smith, H. (1973). The effect of prolonged lithium administration on activity, reactivity, and endurance in the rat. Psychopharmacologia, 30, 83—88. 

Keck PE Jr, Strakowski SMI, Hawkins JM, Dunayevich E, Tugrul KC, Bennett JA, McElroy SL. A pilot study of rapid lithium administration in the treatment of acute mania. Bipolar Disord 2001 3(2) 68-72. 

Cervantes P, Ghadirian AM, Vida S. Vitamin B12 and folate levels and lithium administration in patients with affective disorders. Biol Psychiatry 1999 45(2) 214-21. 

Brambilla, P., Stanley, J.A., Sassi, R.B., Nicoletti, M.A., Mallinger, A.G., Keshavan, M.S., and Soares, J.C., 2004,1H MRS study of dorsolateral prefrontal cortex in healthy individuals before and after lithium administration. Neuropsychopharmacology 29 1918-1924. 

Lithium administration during delivery may be associated with hypotonia in the infant... 

Treatment of lithium-induced polyuria Other complications of lithium administration. Drug interactions ... 

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