Listeria infection

JL-4 on IgE. Excessive IL-4 correlates with elevated IgE and risk of atopy. Kishikawa and coworkers [59] demonstrated that administration of IL-12, a potent Thl-promoting cytokine, to Pb-exposed mice restored the balance of Thl (IFN-y) versus Th2 cytokines (IL-6), which reduce corticosterone levels and enhanced host resistance in Listeria-infected mice. This observation links the role of Thl/Th2 balance in host resistance against disease and the potential signihcance of Pb in the disruption of that balance. 

Sugita-Konishi, Y., et.al., Effect of lactaional exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility ot Listeria infection, Biosci. Biotechnol. Biochem., 67, 89,2003. 

Edelson BT, Unanue ER. Immunity to Listeria infection. Curr Opin Immunol 2000 12 425-31. 

Limaye, A.R, Perkins, J.D., Kowdley, K.V. Listeria infection after liver transplantation report of a case and review of the literature. Amer. J. Gastroenterol. 1998 93 1942-1944... 

Saito, H., Tomioka, H., and Sato, K. 1981. Enhanced resistance of Lactobacillus against Listeria infection in mice. Med. Biol. 102, 273-277. 

The first hints about how actin mediates bacterial movement were provided by a microinjectlon experiment in which fluorescence-labeled G-actIn was Injected into Listeria infected cells. In the microscope, the labeled monomers could be seen incorporating Into the tall-like meshwork at the end... 

Augmentation of the host defense against Listeria infection with normal or murine leukemia viruses, LP-BM5 MuLV infected-immunocompromissed mice by hot water extracts (CVE) administration... 

We have shown that oral administration with hot water extracts (CVE) significantly augmented the host defense against infection with Listeria monocytogenes (L. monocytogenes) [10]. L. monocytogenes is one of an intracellular bacteria, as well as Mycobacterium tuberculosis [11-12]. The protective mechanism against Listeria infection depends mainly on the immune response mediated by ap T cells [13]. 

We have recently reported that y8T cells precede ap T cells in appearance in the peritoneal cavity during Listeria infection and play an important role in protection at the early stage after listerial infection [14-16]. We found that CVE augmented the host defense against Listeria infection by augmenting cell-mediated immunity at the early stage after infection. 

The FCM analysis using mAbs to Thyl.2 and y8 TCR was carried out on the nonadherent population of the PEC in normal mice and CVE-administered mice at the early stage after an i.p. infection with L.monocytogenes (Fig.(2)). Consistent with our previous reports, y8 T cells increased in the PEC of control mice on day 3 and on day 5 after Listeria infection. The increment of the proportion of y8 T cells in the PEC of CVE-administered mice infected with L.monocytogenes was significantly higher than that seen in untreated control mice. 

The DTH response to Listeria antigen in CVE-treated MAIDS mice was significantly higher than that of MAIDS mice on day 7 after Listeria infection, although the response was much lower than in normal mice. 

Oral administration of hot water extracts of Chlorella vulgaris strain CK (CVE) augments the resistance against Listeria infection via development of cell-mediated immunity to Listeria. An increase in the number of y8 T cells at the early stage and that in the number of a(3 T cell, especially CD4+ T cells, at the late stage after infection was evident in CVE-administered mice. Early appearing y8 T cells may be important for the induction of subsequent cell-mediated immunity. 

We demonstrated that oral administration of CVE caused the retention of the capacity of MAIDS mice to eliminate L.monocytogenes in association with an improvement of the defective immune response to L. monocytogenes. CVE is somewhat effective in the treatment of opportunistic Listeria infections in immuno-deficient mice. 

The presence of diphtheroid-like gram-positive rods in the cerebrospinal fluid smear of an 82-year-old patient is indicative of the presence of Listeria monocytogenes. In addition to their role as a potential causative agent in neonatal meningitis, listeria infections are more common in elderly patients and in those who have been treated with immunosuppressive agents. Treatment consists of ampicillin with or without gentamicin. Resistant strains are rare. The answer is (A). 

Pregnant women, the elderly, and those weakened immune systems are at higher risk for severe infections such as Listeria and should be particularly careful not to consume undercooked animal products. They should avoid soft French style cheeses, pates, unctxiked hot dogs and sliced deli meats, which have been sources of Listeria infections. Persons at high risk. should also avoid alfalfa sprouts and unpasteurized Juices. 

Survival rates of Listeria infected mice with and without EPS-pretreatment... 

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