Lindane lotion

Percutaneous absorption studies using a solution of lindane in acetone have shown that almost 10% of a dose applied to the forearm is absorbed, to be subsequently excreted in the urine over a 5-day period. Serum levels following the application of a commercial lindane lotion reach maximum at 6 hours and decline thereafter with a half-life of 24 hours. After absorption, lindane is concentrated in fatty tissues, including the brain. 

Madan V, Jaskiran K, Gupta U, Gupta DK. Oral ivermectin in scabies patients a comparison with 1% topical lindane lotion. J Dermatol 2001 28(9) 481-4. 

Lindane (Kwell, etc) is available as a shampoo or lotion. For pediculosis capitis or pubis, 30 mL of shampoo is applied to dry hair on the scalp or genital area for 4 minutes and then rinsed off. No additional application is indicated unless living lice are present 1 week after treatment. Then reapplication may be required. 

Crotamiton (Eurax) is available as a cream or lotion. Suggested guidelines for scabies treatment call for two applications to the entire body from the chin down at 24-hour intervals, with a cleansing bath 48 hours after the last application. Crotamiton is an effective agent that can be used as an alternative to lindane. Allergic contact hypersensitivity and primary irritation may occur, necessitating discontinuance of therapy. Application to acutely inflamed skin or to the eyes or mucous membranes should be avoided. 

Lindane (Kwell, etc) is available as a shampoo or lotion. For pediculosis capitis or pubis, one application of 30 mL of shampoo is worked into a lather and left on the scalp or genital area for 5 minutes and then rinsed off. No additional application is indicated unless living lice are present 1 week after treatment. Then reapplication may be required. Recent concerns about the toxicity of lindane have altered treatment guidelines for its use in scabies the current recommendation calls for a single application to the entire body from the neck down, left on for 8-12 hours, and then washed off. Patients should be retreated only if active mites can be demonstrated, and never within 1 week of initial treatment. 

Lindane in 1) cream, lotion and shampoo formulations is also used as a parasiticide and ovacide (Kwell) in the treatment of lice (ref. 92, p. 1446). Lindane has a local irritant action and can be absorbed dermally. Acute toxicity in humans may occur by all exposure routes ingestion, inhalation or dermal (ref. 97). All isomers of BHC act on the central nervous system (CNS), but not identically the gamma and... 

A Lindane formulation (mixture of BHC isomers) is used as a termiticide. The 1% shampoo,lotion or cream (Kwell) is also used as an ovacide. The isomer is a CNS stimulant of high acute toxicity, and caused serious illness including convulsions in a patient when administered as a vermifuge. Applications of lindane preparations have resulted in seizures in young children. 

HCH is still used in ointments, lotions, and shampoos to treat head and body lice and scabies. Lindane has not been produced in the United States since 1977. It is still imported and formulated in the United States, although its use is restricted by the USEPA and it can be applied only by a certified applicator. Technical-grade HCH is a mixture of several isomers of HCH. It also was used as an insecticide in the United States, but production stopped in 1983.12,14,48... 

Lindane is a pesticide that is widely used in the treatment of scabies and pediculosis, usually in a 1 % lotion (SEDA-5, 154) (1-4). It is the gamma-isomer of 1,2,3,4,5,6-hexachlorocyclohexane. The hazards of excessive industrial exposure and accidental ingestion have been well documented (3). 

Lindane is u.sed ItKally as a cream, lotion, or shampoo For the treatment of scabies and pediculosis. 

Pulmonary edema has been reported after lindane powder was aspirated into the lungs. An acute dermal poisoning of a 2-month-old infant exposed to a whole body application of 1% y-HCH lotion resulted in death. 

Lindane, a chlorinated hydrocarbon insecticide with scabi-cidal and pedicuhcidal properties (1% cream, lotion, shampoo), is used in scabies and pediculosis. 

Lindane exerts its action by being directly absorbed into the parasite and ova. Lotion nsed in treatment of Sarcoptes scabiei (scabies) in patients who have failed to respond to adeqnate doses or are intolerant of other approved therapies. Shampoo used in treatment of Pediculus capitis (head lice) and Pediculus pubis (crab hce) and their ova in patients who have failed to respond to adequate doses or are intolerant of other approved therapies. 

Perhaps the best known antiectoparasitic medication is 1% y-benzene hexachloride lotion, also known as lindane. 

Lindane, the y isomer of benzene hexachloride, is widely used in the treatment of scabies and pediculosis, usually in a 1% lotion which is applied to the entire body and left on for 24 h (in the case of scabies). The percutaneous absorption of the drug has been widely documented (Ginsburg et al. 1977 Hosier et al. 1980), as has toxicity from excessive topical therapeutic application of lindane (Davies et al. 1983). The issue of possible toxic reactions to a single therapeutic application of lindane, notably CNS toxicity, has not been settled (Food and Drug Administration 1976 Pramanik and Hansen 1979). Most authors agree that the benefits to be derived from the use of lindane as a scabicide and pediculicide outweigh the risks involved (Solomom et al. 1977). 

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